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White matter values of T<jats:sub>2<\/jats:sub> for trimethylamines, creatine and N\u2010acetyl aspartate (NAA) were 309\u00b184, 195\u00b141 and 369\u00b1124ms, respectively (mean\u00b1SD, n = 20). Metabolite concentrations in white matter were 2.0\u00b10.4 m\u0308mol\/g wet weight for trimethylamines, 7.3\u00b11.1 for creatine and 11.4\u00b11.4 for NAA. The mean concentrations of creatine and NAA in grey matter and all of three metabolites in cerebellum were greater than those in white matter. Tumour spectra were characterized by increased trimethylamines, reduced creatine and NAA and occasionally the presence of lactate. Meningiomas were further characterized by the presence of alanine. The mean T<jats:sub>2<\/jats:sub> and concentration of trimethylamines in tumours was significantly greater than in normal brain. Creatine and NAA concentrations were decreased in all tumours. The longer T<jats:sub>2<\/jats:sub> of trimethylamines and presence of alanine in meningiomas indicate that important differences exist in membrane and glucose metabolism within these tumours when compared to either astrocytomas or normal brain tissue.<\/jats:p>","DOI":"10.1002\/nbm.1940080305","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T11:08:33Z","timestamp":1173006513000},"page":"104-112","source":"Crossref","is-referenced-by-count":52,"title":["Determination of proton metabolite concentrations and relaxation parameters in normal human brain and intracranial tumours"],"prefix":"10.1002","volume":"8","author":[{"given":"D. J.","family":"Manton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lowry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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