{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:52:50Z","timestamp":1789559570752,"version":"build-2803163510"},"reference-count":65,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T00:00:00Z","timestamp":1331596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>Noninvasive quantitative MRI methods, such as diffusion tensor imaging (DTI), can offer insights into the structure\u2013function relationships in human developmental brain disorders. In this article, we quantified the macrostructural and microstructural attributes of the corpus callosum (CC) in children with dyslexia and in typically developing readers of comparable age and gender. Diffusion anisotropy, and mean, radial and axial diffusivities of cross\u2010sectional CC subregions were computed using a validated DTI methodology. The normalized posterior CC area was enlarged in children with dyslexia relative to that in typically developing children. Moreover, the callosal microstructural attributes, such as the mean diffusivity of the posterior middle sector of the CC, correlated significantly with measures of word reading and reading comprehension. Reading group differences in fractional anisotropy, mean diffusivity and radial diffusivity were observed in the posterior CC (CC5). This study demonstrates the utility of regional DTI measurements of the CC in understanding the neurobiology of reading disorders. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.2797","type":"journal-article","created":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T01:32:23Z","timestamp":1331602343000},"page":"1263-1270","source":"Crossref","is-referenced-by-count":41,"title":["Diffusion tensor quantification and cognitive correlates of the macrostructure and microstructure of the corpus callosum in typically developing and dyslexic children"],"prefix":"10.1002","volume":"25","author":[{"given":"Khader M.","family":"Hasan","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Imaging University of Texas at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Molfese","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indika S.","family":"Walimuni","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Imaging University of Texas at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla K.","family":"Stuebing","sequence":"additional","affiliation":[{"name":"Texas Institute for Measurement Evaluation and Statistics University of Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Papanicolaou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ponnada A.","family":"Narayana","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Imaging University of Texas at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack M.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,13]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"The Brain Code: Mechanisms of Information Transfer and the Role of the Corpus Callosum","author":"Cook ND","year":"1986"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","DOI":"10.7551\/mitpress\/5233.001.0001","volume-title":"The Parallel Brain: the Cognitive Neuroscience of the Corpus Callosum","author":"Zaidel E","year":"2003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901320103"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198511000-00004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(94)90119-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)90116-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2007.03.008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1286"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.06.030"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.10.026"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.03.072"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90178-C"},{"key":"e_1_2_7_14_1","first-page":"71","article-title":"Anomalies of the corpus callosum: correlation with further anomalies of the brain","volume":"151","author":"Barkovich AJ","year":"1988","journal-title":"Am. 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