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Following Institutional Review Board\u2010approved informed consent and in compliance with the Health Insurance Portability and Accountability Act, successful results were achieved in nine patients with locally advanced cervical cancer [International Federation of Gynecology and Obstetrics (FIGO) stage IIA to IVA] and three normal volunteers. In the first four patients, dynamic <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>*\u2010weighted MRI was performed in the transaxial plane using a multi\u2010shot echo planar imaging sequence whilst patients breathed room air followed by oxygen (15 dm<jats:sup>3<\/jats:sup>\/min). Later, a multi\u2010echo gradient echo examination was added to provide quantitative <jats:italic>R<\/jats:italic><jats:sub>2<\/jats:sub>* measurements. The baseline <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>*\u2010weighted signal intensity was quite stable, but increased to various extents in tumors on initiation of oxygen breathing. The signal in normal uterus increased significantly, whereas that in the iliacus muscle did not change. <jats:italic>R<\/jats:italic><jats:sub>2<\/jats:sub>* responded significantly in healthy uterus, cervix and eight cervical tumors. This preliminary study demonstrates that BOLD MRI of cervical cancer at 3T is feasible. However, more patients must be evaluated and followed clinically before any prognostic value can be determined. 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