{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:46:03Z","timestamp":1771051563633,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T00:00:00Z","timestamp":1354752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>Recent brain imaging studies have emphasized the role of regional brain activity abnormalities in the pathophysiology of functional dyspepsia (FD). However, whether the functional connectivity between brain regions is changed, especially between the cerebral hemispheres, in patients with FD remains unknown. Thus, the present study aimed to examine the interhemispheric resting\u2010state functional connectivity (RSFC) changes in patients with FD. Resting\u2010state functional MRI (fMRI) was performed in 26 patients with FD and in 20 matched healthy controls. An interhemispheric RSFC map was obtained by calculating the Pearson correlation (Fisher <jats:italic>Z<\/jats:italic> transformed) between each pair of homotopic voxel time series for each subject. The between\u2010group difference in interhemispheric RSFC was then examined at global and voxelwise levels separately. The global difference in interhemispheric RSFC between groups was tested using the independent two\u2010sample <jats:italic>t<\/jats:italic>\u2010test. Voxelwise comparisons were carried out using a permutation\u2010based nonparametric test, and multiple comparisons across space were corrected using the threshold\u2010free cluster enhancement (TFCE) method. The results showed that patients with FD had higher global interhemispheric RSFC than healthy controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Furthermore, voxelwise analysis revealed that patients with FD had increased interhemispheric RSFC in brain regions including the anterior cingulate cortex, insula and thalamus (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01, TFCE corrected). Our findings provide preliminary evidence of interhemispheric correlation abnormalities in patients with FD and contribute to a better understanding of the pathophysiology of the disease. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.2878","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T00:22:16Z","timestamp":1354839736000},"page":"410-415","source":"Crossref","is-referenced-by-count":25,"title":["Increased interhemispheric resting\u2010state functional connectivity in functional dyspepsia: a pilot study"],"prefix":"10.1002","volume":"26","author":[{"given":"Guangyu","family":"Zhou","sequence":"first","affiliation":[{"name":"Life Sciences Research Center, School of Life Sciences and Technology Xidian University  Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Life Sciences Research Center, School of Life Sciences and Technology Xidian University  Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Acupuncture and Tuina School\/The 3rd Teaching Hospital Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Yuan","sequence":"additional","affiliation":[{"name":"Life Sciences Research Center, School of Life Sciences and Technology Xidian University  Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dahua","family":"Yu","sequence":"additional","affiliation":[{"name":"Life Sciences Research Center, School of Life Sciences and Technology Xidian University  Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen M.","family":"von Deneen","sequence":"additional","affiliation":[{"name":"Life Sciences Research Center, School of Life Sciences and Technology Xidian University  Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanrong","family":"Liang","sequence":"additional","affiliation":[{"name":"Acupuncture and Tuina School\/The 3rd Teaching Hospital Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Qin","sequence":"additional","affiliation":[{"name":"Life Sciences Research Center, School of Life Sciences and Technology Xidian University  Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[{"name":"Life Sciences Research Center, School of Life Sciences and Technology Xidian University  Xi'an Shaanxi China"},{"name":"Institute of Automation Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.05.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-012309-103958"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.39"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.04.015"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.037"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.054"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2201"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq190"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2612-10.2010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4544-08.2008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.08.018"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.11.022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01363.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3173"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(71)71479-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1965.01730060026004"},{"key":"e_1_2_7_19_1","first-page":"44","article-title":"Shanghai Arch","volume":"2","author":"Wu W","year":"1990","journal-title":"Psychol."},{"issue":"5","key":"e_1_2_7_20_1","first-page":"267","article-title":"Self\u2010Rating Depression Scale (SDS): an analysis on 1340 health subjects","volume":"12","author":"Chunfang W","year":"1986","journal-title":"Chin. J. Nervous Mental Dis."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(01)00036-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0315"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.01045.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21201"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.10.026"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2004.04.010"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01304.x"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnbm.2878","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.2878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:40:54Z","timestamp":1760960454000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.2878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,6]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1002\/nbm.2878"],"URL":"https:\/\/doi.org\/10.1002\/nbm.2878","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,6]]}}}