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Previous functional neuroimaging studies used visual stimuli to examine abnormal activities in the eating\u2010related neural circuitry of patients with PWS. It was found that patients with PWS exhibited both excessive hunger and hyperphagia consistently, even in situations without any food stimulation. In the present study, we employed resting\u2010state functional MRI techniques to investigate abnormal brain networks related to eating disorders in children with PWS. First, we applied amplitude of low\u2010frequency fluctuation analysis to define the regions of interest that showed significant alterations in resting\u2010state brain activity levels in patients compared with their sibling control group. We then applied a functional connectivity (FC) analysis to these regions of interest in order to characterize interactions among the brain regions. Our results demonstrated that patients with PWS showed decreased FC strength in the medial prefrontal cortex (MPFC)\/inferior parietal lobe (IPL), MPFC\/precuneus, IPL\/precuneus and IPL\/hippocampus in the default mode network; decreased FC strength in the pre\u2010\/postcentral gyri and dorsolateral prefrontal cortex (DLPFC)\/orbitofrontal cortex (OFC) in the motor sensory network and prefrontal cortex network, respectively; and increased FC strength in the anterior cingulate cortex\/insula, ventrolateral prefrontal cortex (VLPFC)\/OFC and DLPFC\/VLPFC in the core network and prefrontal cortex network, respectively. These findings indicate that there are FC alterations among the brain regions implicated in eating as well as rewarding, even during the resting state, which may provide further evidence supporting the use of PWS as a model to study obesity and to provide information on potential neural targets for the medical treatment of overeating. 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