{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:45:57Z","timestamp":1791488757472,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,7,26]],"date-time":"2014-07-26T00:00:00Z","timestamp":1406332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Subcutaneous (SAT) and visceral adipose tissue (VAT) differ in composition, endocrine function and localization in the body. VAT is considered to play a role in the pathogenesis of insulin resistance, type 2 diabetes, fatty liver disease, and other obesity\u2010related disorders. It has been shown that the amount, distribution, and (cellular) composition of adipose tissue (AT) correlate well with metabolic conditions. In this study, <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> relaxation times of AT were measured in severely obese subjects and compared with those of healthy lean controls. Here, we tested the hypothesis that <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> relaxation times of AT differ between lean and obese individuals, but also between VAT and SAT as well as superficial (sSAT) and deep SAT (dSAT) in the same individual.<\/jats:p><jats:p>Twenty severely obese subjects (BMI 41.4\u2009\u00b1\u20094.8\u2009kg\/m<jats:sup>2<\/jats:sup>) and ten healthy lean controls matched for age (BMI 21.5\u2009\u00b1\u20091.9\u2009kg\/m<jats:sup>2<\/jats:sup>) underwent MRI at 1.5\u2009T using a single\u2010shot fast spin\u2010echo sequence (short\u2010tau inversion recovery) at six different inversion times (<jats:italic>T<\/jats:italic><jats:sub>I<\/jats:sub> range 100\u20131000\u2009ms). <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> relaxation times were computed for all subjects by fitting the <jats:italic>T<\/jats:italic><jats:sub>I<\/jats:sub>\u2010dependent MR signal intensities of user\u2010defined regions of interest in both SAT and VAT to a model function. <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> times in sSAT and dSAT were only measured in obese patients. For both obese patients and controls, the <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> times of SAT (275\u2009\u00b1\u200914 and 301\u2009\u00b1\u200912\u2009ms) were significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) shorter than the respective values in VAT (294\u2009\u00b1\u200920 and 360\u2009\u00b1\u200935\u2009ms). Obese subjects also showed significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> differences between sSAT (268\u2009\u00b1\u200911\u2009ms) and dSAT (281\u2009\u00b1\u200919\u2009ms). More important, <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> differences in both SAT and VAT were highly significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) between obese patients and healthy subjects.<\/jats:p><jats:p>The results of our pilot study suggest that <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> relaxation times differ between severely obese patients and lean controls, and may potentially provide an additional means for the non\u2010invasive assessment of AT conditions and dysfunction. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.3166","type":"journal-article","created":{"date-parts":[[2014,7,26]],"date-time":"2014-07-26T04:48:40Z","timestamp":1406350120000},"page":"1123-1128","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of <i>T<\/i><sub>1<\/sub> relaxation times in adipose tissue of severely obese patients and healthy lean subjects measured by 1.5\u2009T MRI"],"prefix":"10.1002","volume":"27","author":[{"given":"Nikita","family":"Garnov","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Leipzig University Hospital  Leipzig Germany"},{"name":"Integrated Research and Treatment Center (IFB) Adiposity Diseases Leipzig University Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Linder","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Leipzig University Hospital  Leipzig Germany"},{"name":"Integrated Research and Treatment Center (IFB) Adiposity Diseases Leipzig University Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Schaudinn","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Leipzig University Hospital  Leipzig Germany"},{"name":"Integrated Research and Treatment Center (IFB) Adiposity Diseases Leipzig University Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Bl\u00fcher","sequence":"additional","affiliation":[{"name":"Integrated Research and Treatment Center (IFB) Adiposity Diseases Leipzig University Medical Center  Leipzig Germany"},{"name":"Department of Internal Medicine, Endocrinology and Nephrology Leipzig University Hospital  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Karlas","sequence":"additional","affiliation":[{"name":"Integrated Research and Treatment Center (IFB) Adiposity Diseases Leipzig University Medical Center  Leipzig Germany"},{"name":"Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology and Rheumatology Leipzig University Hospital  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Sch\u00fctz","sequence":"additional","affiliation":[{"name":"Integrated Research and Treatment Center (IFB) Adiposity Diseases Leipzig University Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Integrated Research and Treatment Center (IFB) Adiposity Diseases Leipzig University Medical Center  Leipzig Germany"},{"name":"Clinic of Visceral, Transplantation, Thoracic 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