{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:02:21Z","timestamp":1789448541583,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:00:00Z","timestamp":1407110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030_144075\/1"],"award-info":[{"award-number":["310030_144075\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["316030_139258\/1"],"award-info":[{"award-number":["316030_139258\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>The goal of this study was to test the potential of ultra\u2010short echo\u2010time (UTE) MRI at 1.5, 3.0 and 7.0\u2009T for depiction of trabecular bone structure (of the wrist bones), to evaluate whether <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* relaxation times of bone water and parametric maps of <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* of trabecular bone could be obtained at all three field strengths, and to compare the <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* relaxation times with structural parameters obtained from micro\u2010computed tomography (micro\u2010CT) as a reference standard. <jats:italic>Ex vivo<\/jats:italic> carpal bones of six wrists were excised <jats:italic>en bloc<\/jats:italic> and underwent MRI at 1.5, 3.0 and 7.0\u2009T in a whole\u2010body MR imager using the head coil. A three\u2010dimensional radial fat\u2010suppressed UTE sequence was applied with subsequent acquisitions, with six different echo times <jats:italic>T<\/jats:italic><jats:sub>E<\/jats:sub> of 150, 300, 600, 1200, 3500 and 7000\u2009\u00b5s. The <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* relaxation time and pixel\u2010wise computed <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* parametric maps were compared with a micro\u2010computed\u2010tomography reference standard providing trabecular bone structural parameters including porosity (defined as the bone\u2010free fraction within a region of interest), trabecular thickness, trabecular separation, trabecular number and fractal dimension (<jats:italic>D<jats:sub>k<\/jats:sub><\/jats:italic>). <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* relaxation curves and parametric maps could be computed from datasets acquired at all field strengths. Mean <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* relaxation times of trabecular bone were 4580\u2009\u00b1\u20091040\u2009\u00b5s at 1.5\u2009T, 2420\u2009\u00b1\u2009560\u2009\u00b5s at 3.0\u2009T and 1220\u2009\u00b1\u2009300\u2009\u00b5s at 7.0\u2009T, when averaged over all carpal bones. A positive correlation of <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* with trabecular bone porosity and trabecular separation, and a negative correlation of <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* relaxation time with trabecular thickness, trabecular number and fractal dimension, was detected (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01 for all field strengths and micro\u2010CT parameters). We conclude that UTE MRI may be useful to characterize the structure of trabecular bone, comparable to micro\u2010CT. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.3169","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T06:11:05Z","timestamp":1407132665000},"page":"1159-1166","source":"Crossref","is-referenced-by-count":41,"title":["Characterization of trabecular bone density with ultra\u2010short echo\u2010time MRI at 1.5, 3.0 and 7.0\u2009T \u2013 comparison with micro\u2010computed tomography"],"prefix":"10.1002","volume":"27","author":[{"given":"Moritz C.","family":"Wurnig","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Zurich  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Calcagni","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery University Hospital Zurich  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