{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:25:43Z","timestamp":1789377943920,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:00:00Z","timestamp":1407110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2014,10]]},"abstract":"\n The purpose of this study was to correlate intravoxel incoherent motion (IVIM) imaging with classical perfusion\u2010weighted MRI metrics in human gliomas. Parametric images for slow diffusion coefficient (\n D<\/jats:italic>\n ), fast diffusion coefficient (\n D<\/jats:italic>\n *), and fractional perfusion\u2010related volume (\n f<\/jats:italic>\n ) in patients with high\u2010grade gliomas were generated. Maps of\n F<\/jats:italic>\n p<\/jats:sub>\n (plasma flow),\n v<\/jats:italic>\n p<\/jats:sub>\n (vascular plasma volume),\n PS<\/jats:italic>\n (permeability surface\u2013area product),\n v<\/jats:italic>\n e<\/jats:sub>\n (extravascular, extracellular volume),\n E<\/jats:italic>\n (extraction ratio),\n k<\/jats:italic>\n e<\/jats:sub>\n (influx ratio into the interstitium), and\n t<\/jats:italic>\n c<\/jats:sub>\n (vascular transit time) from dynamic contrast\u2010enhanced (DCE) and dynamic susceptibility contrast\u2010enhanced (DSC) MRI were also generated. A region\u2010of\u2010interest analysis on the contralateral healthy white matter and on the tumor areas was performed and the extracted parameter values were tested for any significant differences among tumor grades or any correlations. Only\n f<\/jats:italic>\n could be significantly correlated to DSC\u2010derived\n v<\/jats:italic>\n p<\/jats:sub>\n and\n t<\/jats:italic>\n c<\/jats:sub>\n in healthy brain tissue. Concerning the tumor regions,\n F<\/jats:italic>\n p<\/jats:sub>\n was significantly positively correlated with\n D<\/jats:italic>\n * and inversely correlated with\n f<\/jats:italic>\n in DSC measurements. The\n D<\/jats:italic>\n *,\n f<\/jats:italic>\n , and\n f<\/jats:italic>\n \u2009\u00d7\u2009\n D<\/jats:italic>\n * values in the WHO grade III gliomas were non\u2010significantly different from those in the grade IV gliomas. There was a trend to significant negative correlations between\n f<\/jats:italic>\n and\n PS<\/jats:italic>\n as well as between\n f<\/jats:italic>\n \u2009\u00d7\u2009\n D<\/jats:italic>\n * and\n k<\/jats:italic>\n e<\/jats:sub>\n in DCE experiments. Presumably due to different theoretical background, tracer properties and modeling of the tumor vasculature in the IVIM theory, there is no clearly evident link between\n D<\/jats:italic>\n *,\n f<\/jats:italic>\n and DSC\u2010 and DCE\u2010derived metrics. Copyright \u00a9 2014 John Wiley & Sons, Ltd.\n <\/jats:p>","DOI":"10.1002\/nbm.3172","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T06:53:03Z","timestamp":1407135183000},"page":"1184-1191","source":"Crossref","is-referenced-by-count":58,"title":["Correlative assessment of tumor microcirculation using contrast\u2010enhanced perfusion MRI and intravoxel incoherent motion diffusion\u2010weighted MRI: is there a link between them?"],"prefix":"10.1002","volume":"27","author":[{"given":"Sotirios","family":"Bisdas","sequence":"first","affiliation":[{"name":"Department of Neuroradiology Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Neurology Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Skardelly","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Schittenhelm","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze Hern","family":"Teo","sequence":"additional","affiliation":[{"name":"Department of Oncologic Imaging National Cancer Center Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon Hua","family":"Thng","sequence":"additional","affiliation":[{"name":"Department of Oncologic Imaging National Cancer Center Singapore"},{"name":"Center for Quantitative Medicine Duke\u2010NUS Graduate Medical School Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Klose","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong San","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Oncologic Imaging National Cancer Center Singapore"},{"name":"Center for Quantitative Medicine Duke\u2010NUS Graduate Medical School 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