{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:49:40Z","timestamp":1789422580826,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T00:00:00Z","timestamp":1414454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR063894-01A1"],"award-info":[{"award-number":["AR063894-01A1"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR062581-01A1"],"award-info":[{"award-number":["AR062581-01A1"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1IK2CX000749"],"award-info":[{"award-number":["1IK2CX000749"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Water is present in cortical bone in different binding states. In this study we aimed to investigate the effects of inversion time (TI) on the signal from bound and pore water in cortical bone using an adiabatic inversion recovery prepared ultrashort echo time (IR\u2010UTE) sequence on a clinical 3\u2009T scanner. In total ten bovine midshaft samples and four human tibial midshaft samples were harvested for this study. Each cortical sample was imaged with the UTE and IR\u2010UTE sequences with a TR of 300\u2009ms and a series of TI values ranging from 10 to 240\u2009ms. Five healthy volunteers were also imaged with the same sequence. Single\u2010 and bi\u2010component models were utilized to calculate the <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* and relative fractions of short and long T<jats:sub>2<\/jats:sub>* components. Bi\u2010component behavior of the signal from cortical bone was seen with the IR\u2010UTE sequence, except with a TI of around 80\u2009ms, where the short <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* component alone were seen and a mono\u2010exponential decay pattern was observed. <jats:italic>In vivo<\/jats:italic> imaging with the IR\u2010UTE sequence provided high contrast\u2010to\u2010noise images with direct visualization of bound water and reduced signal from long <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> muscle and fat. Our preliminary results demonstrate that selective nulling of the pore water component can be achieved with the IR\u2010UTE sequence with an appropriate TI, allowing selective imaging of the bound water component in cortical bone <jats:italic>in vivo<\/jats:italic> using clinical MR scanners. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.3228","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T05:59:14Z","timestamp":1414475954000},"page":"70-78","source":"Crossref","is-referenced-by-count":35,"title":["Effects of inversion time on inversion recovery prepared ultrashort echo time (IR\u2010UTE) imaging of bound and pore water in cortical bone"],"prefix":"10.1002","volume":"28","author":[{"given":"Shihong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology, Hua Dong Hospital Fudan University  Shanghai China"},{"name":"Department of Radiology University of California  San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanqing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California  San Diego CA USA"},{"name":"Department of Gastroenterology First Hospital of Kunming Medical University  Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Y.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California  San Diego CA USA"},{"name":"Department of Radiology VA San Diego Healthcare System  La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongda","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California  San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California  San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine B.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California  San Diego CA USA"},{"name":"Department of Radiology VA San Diego Healthcare System  La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme M.","family":"Bydder","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California  San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California  San Diego CA USA"},{"name":"Department of Radiology VA San Diego Healthcare System  La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02409497"},{"issue":"1","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2106\/00004623-195739010-00015","article-title":"The water content of bone. 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