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This rapid increase indicates the growing interest in ultrahigh\u2010field MRI because of improved clinical results with regard to morphological as well as functional and metabolic capabilities. As the signal\u2010to\u2010noise ratio scales linearly with the field strength (B\n                    <jats:sub>0<\/jats:sub>\n                    ) of the scanner, the most obvious application at 7\u2009T is to obtain higher spatial resolution in the brain, musculoskeletal system and breast. Of specific clinical interest for neuro\u2010applications is the cerebral cortex at 7\u2009T, for the detection of changes in cortical structure as a sign of early dementia, as well as for the visualization of cortical microinfarcts and cortical plaques in multiple sclerosis. In the imaging of the hippocampus, even subfields of the internal hippocampal anatomy and pathology can be visualized with excellent resolution. The dynamic and static blood oxygenation level\u2010dependent contrast increases linearly with the field strength, which significantly improves the pre\u2010surgical evaluation of eloquent areas before tumor removal. Using susceptibility\u2010weighted imaging, the plaque\u2013vessel relationship and iron accumulation in multiple sclerosis can be visualized for the first time. Multi\u2010nuclear clinical applications, such as sodium imaging for the evaluation of repair tissue quality after cartilage transplantation and\n                    <jats:sup>31<\/jats:sup>\n                    P spectroscopy for the differentiation between non\u2010alcoholic benign liver disease and potentially progressive steatohepatitis, are only possible at ultrahigh fields. Although neuro\u2010 and musculoskeletal imaging have already demonstrated the clinical superiority of ultrahigh fields, whole\u2010body clinical applications at 7\u2009T are still limited, mainly because of the lack of suitable coils. The purpose of this article was therefore to review the clinical studies that have been performed thus far at 7\u2009T, compared with 3\u2009T, as well as those studies performed at 7\u2009T that cannot be routinely performed at 3\u2009T. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/nbm.3272","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T02:41:59Z","timestamp":1426128119000},"page":"1316-1334","source":"Crossref","is-referenced-by-count":63,"title":["Clinical applications at ultrahigh field (7\u2009\u2009T). 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