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Currently available time\u2010 and frequency\u2010domain analysis software includes AMARES (in jMRUI) and CFIT respectively. Another popular frequency\u2010domain approach is LCModel, which has been successfully used to fit both <jats:sup>1<\/jats:sup>H and <jats:sup>13<\/jats:sup>C <jats:italic>in vivo<\/jats:italic> NMR spectra. To the best of our knowledge LCModel has not been used to fit <jats:sup>31<\/jats:sup>P spectra. This study demonstrates the feasibility of using LCModel to quantify <jats:italic>in vivo<\/jats:italic> <jats:sup>31<\/jats:sup>P MR spectra, provided that adequate prior knowledge and LCModel control parameters are used. Both single\u2010voxel and MRSI data are presented, and similar results are obtained with LCModel and with AMARES. This provides a new method for automated, operator\u2010independent analysis of <jats:sup>31<\/jats:sup>P NMR spectra. 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