{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:25:56Z","timestamp":1761006356222,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,5]],"date-time":"2015-07-05T00:00:00Z","timestamp":1436054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["13514","2010-4454"],"award-info":[{"award-number":["13514","2010-4454"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish Cancer Society","award":["CAN 2012\/597"],"award-info":[{"award-number":["CAN 2012\/597"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Most approaches to arterial spin labelling (ASL) data analysis aim to provide a quantitative measure of the cerebral blood flow (CBF). This study, however, focuses on the measurement of the transfer time of blood water through the capillaries to the parenchyma (referred to as the capillary transfer time, CTT) as an alternative parameter to characterise the haemodynamics of the system. The method employed is based on a non\u2010compartmental model, and no measurements need to be added to a common time\u2010resolved ASL experiment. Brownian motion of labelled spins in a potential was described by a one\u2010dimensional general Langevin equation as the starting point, and as a Fokker\u2013Planck differential equation for the averaged distribution of labelled spins at the end point, which takes into account the effects of flow and dispersion of labelled water by the pseudorandom nature of the microvasculature and the transcapillary permeability. Multi\u2010inversion time (multi\u2010TI) ASL data were acquired in 14 healthy subjects on two occasions in a test\u2013retest design, using a pulsed ASL sequence and three\u2010dimensional gradient and spin echo (3D\u2010GRASE) readout. Based on an error analysis to predict the size of a region of interest (ROI) required to obtain reasonably precise parameter estimates, data were analysed in two relatively large ROIs, i.e. the occipital lobe (OC) and the insular cortex (IC). The average values of CTT in OC were 260\u2009\u00b1\u200960\u2009ms in the first experiment and 270\u2009\u00b1\u200960\u2009ms in the second experiment. The corresponding IC values were 460\u2009\u00b1\u2009130\u2009ms and 420\u2009\u00b1\u2009139\u2009ms, respectively. Information related to the water transfer time may be important for diagnostics and follow\u2010up of cerebral conditions or diseases characterised by a disrupted blood\u2013brain barrier or disturbed capillary blood flow. 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