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Examinations carried out at 3\u2009T comprised multi\u2010slice 17\u2010echo measurements of muscle water <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> and heterogeneity, three\u2010point Dixon imaging of fat fraction in flexor and extensor muscles (FLEX, EXT), and non\u2010localised spectroscopy of phosphate metabolites. We studied four imaging indices, eight metabolic ratios combining ATP, phosphocreatine, phosphomonoesters and phosphodiesters, the cytosolic inorganic phosphate (Pi<jats:sub>a<\/jats:sub>) and an alkaline (Pi<jats:sub>b<\/jats:sub>) pool present in dystrophic muscle, and average pH. All indices differed between DMD and CONT, except for muscle water <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>. Measurements were outside the 95th percentile of age\u2010matched CONT values in over 65% of cases for percentage fat signal (%F), and in 78\u2013100% of cases for all spectroscopic indices. <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> was elevated in one\u2010third of FLEX measurements, whereas %pixels\u2009&gt;\u200939\u2009ms and <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> heterogeneity were abnormal in one\u2010half of the examinations. The FLEX muscles had higher fat infiltration and <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> than EXT muscle groups. All indices, except pH, correlated with patient age, although the correlation was negative for <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>. However, in non\u2010ambulant patients, the correlation with years since loss of ambulation was stronger than the correlation with age, and the slope of evolution per year was steeper after loss of ambulation. All indices except Pi\/gATP differed between ambulant and non\u2010ambulant patients; however, <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> and %pixels\u2009&gt;\u200939\u2009ms were highest in ambulant patients, possibly owing to the greater extent of inflammatory processes earlier in the disease. All other indices were worse in non\u2010ambulant subjects. Quantitative measurements obtained from patients at different disease stages covered a broad range of abnormalities that evolved with the disease, and metabolic indices were up to 10\u2010fold above normal from the onset, thus establishing a variety of potential markers for future therapy. 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