{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T18:02:44Z","timestamp":1770573764019,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T00:00:00Z","timestamp":1442361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Capecitabine (Cap) is an often prescribed chemotherapeutic agent, successfully used to cure some patients from cancer or reduce tumor burden for palliative care. However, the efficacy of the drug is limited, it is not known in advance who will respond to the drug and it can come with severe toxicity. <jats:sup>19<\/jats:sup>\u2009F Magnetic Resonance Spectroscopy (MRS) and Magnetic Resonance Spectroscopic Imaging (MRSI) have been used to non\u2010invasively study Cap metabolism <jats:italic>in vivo<\/jats:italic> to find a marker for personalized treatment. <jats:italic>In vivo<\/jats:italic> detection, however, is hampered by low concentrations and the use of radiofrequency (RF) surface coils limiting spatial coverage. In this work, the use of a 7T MR system with radiative multi\u2010channel transmit\u2013receive antennas was investigated with the aim of maximizing the sensitivity and spatial coverage of <jats:sup>19<\/jats:sup>\u2009F detection protocols. The antennas were broadband optimized to facilitate both the <jats:sup>1<\/jats:sup>H (298\u2009MHz) and <jats:sup>19<\/jats:sup>\u2009F (280\u2009MHz) frequencies for accurate shimming, imaging and signal combination. <jats:italic>B<\/jats:italic><jats:sub>1<\/jats:sub><jats:sup>+<\/jats:sup> simulations, phantom and noise measurements showed that more than 90% of the theoretical maximum sensitivity could be obtained when using <jats:italic>B<\/jats:italic><jats:sub>1<\/jats:sub><jats:sup>+<\/jats:sup> and <jats:italic>B<\/jats:italic><jats:sub>1<\/jats:sub><jats:sup>\u2212<\/jats:sup> information provided at the <jats:sup>1<\/jats:sup>H frequency for the optimization of <jats:italic>B<\/jats:italic><jats:sub>1<\/jats:sub><jats:sup>+<\/jats:sup> and <jats:italic>B<\/jats:italic><jats:sub>1<\/jats:sub><jats:sup>\u2212<\/jats:sup> at the <jats:sup>19<\/jats:sup>\u2009F frequency. Furthermore, to overcome the limits in maximum available RF power, whilst ensuring simultaneous excitation of all detectable conversion products of Cap, a dual\u2010band RF pulse was designed and evaluated. Finally, <jats:sup>19<\/jats:sup>\u2009F MRS(I) measurements were performed to detect <jats:sup>19<\/jats:sup>\u2009F metabolites <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. In two patients, at 10\u2009h (patient 1) and 1\u2009h (patient 2) after Cap intake, <jats:sup>19<\/jats:sup>\u2009F metabolites were detected in the liver and the surrounding organs, illustrating the potential of the set\u2010up for <jats:italic>in vivo<\/jats:italic> detection of metabolic rates and drug distribution in the body. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.3390","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T02:52:50Z","timestamp":1442371970000},"page":"1433-1442","source":"Crossref","is-referenced-by-count":13,"title":["<sup>19<\/sup>\u2009F MRSI of capecitabine in the liver at 7\u2009T using broadband transmit\u2013receive antennas and dual\u2010band RF pulses"],"prefix":"10.1002","volume":"28","author":[{"given":"Jetse S.","family":"van Gorp","sequence":"first","affiliation":[{"name":"University Medical Center Utrecht Image Sciences Institute  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Seevinck","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht Image Sciences Institute  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Andreychenko","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht Radiotherapy  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J. 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