{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:29:14Z","timestamp":1790008154212,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T00:00:00Z","timestamp":1445904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>This study sought to demonstrate and evaluate a novel spectral fitting method to improve quantification accuracy in the presence of large magnetic field distortion, especially with high fields. MRS experiments were performed using a point\u2010resolved spectroscopy (PRESS)\u2010type sequence at 7\u2009T. A double\u2010echo gradient echo (GRE) sequence was used to acquire <jats:italic>B<\/jats:italic><jats:sub>0<\/jats:sub> maps following MRS experiments. The basis set was modified based on the measured <jats:italic>B<\/jats:italic><jats:sub>0<\/jats:sub> distribution within the MRS voxel. Quantification results were obtained after fitting the measured MRS data using the modified basis set. The proposed method was validated using numerical Monte Carlo simulations, phantom measurements, and comparison of occipital lobe MRS measurements under homogeneous and inhomogeneous magnetic field conditions. <jats:italic>In vivo<\/jats:italic> results acquired from voxels placed in thalamus and prefrontal cortex regions close to the frontal sinus agreed well with published values. Instead of noise\u2010amplifying complex division, the proposed method treats field variations as part of the signal model, thereby avoiding inherent statistical bias associated with regularization. Simulations and experiments showed that the proposed approach reliably quantified results in the presence of relatively large magnetic field distortion. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.<\/jats:p>","DOI":"10.1002\/nbm.3430","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T06:27:02Z","timestamp":1445927222000},"page":"1707-1715","source":"Crossref","is-referenced-by-count":15,"title":["Spectral fitting using basis set modified by measured <i>B<\/i><sub>0<\/sub> field distribution"],"prefix":"10.1002","volume":"28","author":[{"given":"Ningzhi","family":"Li","sequence":"first","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health National Institutes of Health  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"An","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health National Institutes of Health  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shen","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health National Institutes of Health  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2004.12.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2004.12.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.12.008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2012.02.003"},{"key":"e_1_2_9_6_1","first-page":"226","article-title":"1H magnetic resonance spectroscopy imaging of prefrontal region and hippocampus in patients with obsessive\u2013compulsive disorder","volume":"29","author":"Lu YR","year":"2007","journal-title":"Zhejiang Med. 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