{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:25:26Z","timestamp":1770740726222,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Recent studies have shown that post\u2010treatment with cocaine\u2010 and amphetamine\u2010regulated transcript (CART) has neuroregenerative effects in animal models of stroke. The purpose of this study was to characterize CART\u2010mediated neuronal and vascular repairments using non\u2010invasive MRI techniques. Adult male rats were subjected to a 90 min middle cerebral artery occlusion (MCAo). Animals were separated into two groups with similar infarction sizes, measured by <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010weighted MRI on Day 2 after MCAo, and were treated with CART or vehicle intranasally from Day 3 to Day 12. Diffusion tensor imaging was used to examine changes in plasticity of white matter elements. Susceptibility\u2010weighted imaging (SWI) was used to measure angiogenesis. Post\u2010treatment with CART significantly increased fractional anisotropy (FA) in lesioned cortex on Days 10 and 25 post stroke. A significant correlation between the behavioral recovery in body asymmetry and the change in FA was shown, suggesting that behavioral recovery was associated with reinnervation to the lesioned hemisphere. CART also increased the intensity of SWI and the immunoreactivity of the vascular marker alpha\u2010smooth muscle actin in lesioned cortex. Together, our data support a non\u2010invasive treatment strategy for stroke through angiogenesis and reinnervation by CART. 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