{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T04:47:48Z","timestamp":1794026868610,"version":"4.8.0"},"reference-count":62,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>The basal ganglia are key structures for motor, cognitive and behavioral functions. They undergo several changes with aging and disease, such as Parkinson's or Huntington's disease, for example. Iron accumulation in basal ganglia is often related to these diseases, which is conventionally monitored by the transverse relaxation rate (<jats:italic>R<\/jats:italic><jats:sub>2<\/jats:sub>*). Quantitative susceptibility mapping (QSM) is a novel contrast mechanism in MRI produced by adding information taken from the phase of the MR signal to its magnitude. It has been shown to be more sensitive to subtle changes in <jats:styled-content style=\"fixed-case\">Parkinson's disease<\/jats:styled-content>. In order to be applied widely to various pathologies, its reproducibility must be evaluated in order to assess intra\u2010subject variability and to disseminate into clinical and pharmaceutical studies. In this work, we studied the reproducibility and sensitivity of several QSM techniques. Fourteen subjects were scanned four times, and QSM and <jats:italic>R<\/jats:italic><jats:sub>2<\/jats:sub>* images were reconstructed and registered. An atlas of the basal ganglia was used to automatically define regions of interest. We found that QSM measurements are indeed reproducible in the basal ganglia of healthy subjects and can be widely used as a replacement for <jats:italic>R<\/jats:italic><jats:sub>2<\/jats:sub>* mapping in iron\u2010rich regions. This reproducibility study could lead to several lines of research in relaxometry and susceptibility measurements, <jats:italic>in vivo<\/jats:italic> iron load evaluation as well as pharmacological assessment and biomarker development. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.3491","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T21:46:19Z","timestamp":1456436779000},"source":"Crossref","is-referenced-by-count":62,"title":["Reproducibility of <i>R<\/i><sub>2<\/sub>* and quantitative susceptibility mapping (QSM) reconstruction methods in the basal ganglia of healthy subjects"],"prefix":"10.1002","volume":"30","author":[{"given":"M. D.","family":"Santin","sequence":"first","affiliation":[{"name":"CENIR Centre de NeuroImagerie de Recherche  Paris France"},{"name":"ICM Inserm U 1127, CNRS UMR 7225, Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Didier","sequence":"additional","affiliation":[{"name":"CENIR Centre de NeuroImagerie de Recherche  Paris France"},{"name":"ICM Inserm U 1127, CNRS UMR 7225, Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Valabr\u00e8gue","sequence":"additional","affiliation":[{"name":"CENIR Centre de NeuroImagerie de Recherche  Paris France"},{"name":"ICM Inserm U 1127, CNRS UMR 7225, Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Yahia Cherif","sequence":"additional","affiliation":[{"name":"CENIR Centre de NeuroImagerie de Recherche  Paris France"},{"name":"ICM Inserm U 1127, CNRS UMR 7225, Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Garc\u00eda\u2010Lorenzo","sequence":"additional","affiliation":[{"name":"CENIR Centre de NeuroImagerie de Recherche  Paris France"},{"name":"ICM Inserm U 1127, CNRS UMR 7225, Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Loureiro de Sousa","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, CNRS, ICube (UMR 7357), FMTS  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bardinet","sequence":"additional","affiliation":[{"name":"CENIR Centre de NeuroImagerie de Recherche  Paris France"},{"name":"ICM Inserm U 1127, CNRS UMR 7225, Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Leh\u00e9ricy","sequence":"additional","affiliation":[{"name":"CENIR Centre de NeuroImagerie de Recherche  Paris France"},{"name":"ICM Inserm U 1127, CNRS UMR 7225, Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2915"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.129"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-015-9292-y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20698"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009258"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910320309"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100495"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20244"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26218"},{"key":"e_1_2_7_11_1","first-page":"450","article-title":"Voxel\u2010based relaxometry of transverse relaxation rate with gradient echo R2(*) in patients with multiple system atrophy","volume":"34","author":"Hou B","year":"2012","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2865"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22019"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21710"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2015.08.003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25420"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12120707"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13121991"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2015.02.021"},{"key":"e_1_2_7_20_1","article-title":"Iron accumulation in the basal ganglia in Huntington's disease: cross\u2010sectional data from the IMAGE\u2010HD study","author":"Dom\u00ednguez DJF","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081093"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4260"},{"key":"e_1_2_7_23_1","article-title":"Quantitative susceptibility mapping of the midbrain in Parkinson's disease","author":"Du G","year":"2015","journal-title":"Mov. Disord."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24943"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000159"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.077"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2009.01.006"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.28.001194"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24405"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.10.070"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3064"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22816"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22135"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22334"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22187"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.082"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24272"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3171\/2008.3.17469"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.86.2.420"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1519\/15184.1"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.04.021"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199901)41:1<193::AID-MRM27>3.0.CO;2-P"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980115)17:1<101::AID-SIM727>3.0.CO;2-E"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.06.035"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2002.803106"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25247"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.10.037"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24897"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24932"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24765"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1670"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22276"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.05.067"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25015"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.09.013"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.05.049"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057904"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21828"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22928"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq212"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000286384.31050.b5"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2765"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.11.009"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnbm.3491","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnbm.3491","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.3491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:35:56Z","timestamp":1760952956000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.3491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,23]]},"references-count":62,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1002\/nbm.3491"],"URL":"https:\/\/doi.org\/10.1002\/nbm.3491","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,23]]},"article-number":"e3491"}}