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Several metabolite concentration ratios in the visual cortex were calculated. In addition, postmortem histologic analyses for retinal ganglion cell (RGC) loss, optic nerve injury and visual cortex alterations were monitored. The results showed that diabetes induced several changes in visual cortex metabolites, such as reduced N\u2010acetylaspartate, glutamate, \u03b3\u2010aminobutyric acid, taurine and choline\u2010containing compound levels. Nevertheless, myo\u2010inositol levels increased significantly as compared with controls. Remarkable RGC loss and optic nerve degeneration were observed by morphological analysis. Moreover, the results showed significant neuronal loss and glial activation in the visual cortex. These findings indicated that, besides vascular abnormalities, neuronal loss and degeneration in the visual pathway were induced due to disrupted glucose homeostasis in diabetes. Metabolic or functional abnormalities were induced in cerebral neurons of the visual cortex by diabetes.<\/jats:p>","DOI":"10.1002\/nbm.3783","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T13:03:56Z","timestamp":1505480636000},"source":"Crossref","is-referenced-by-count":9,"title":["Metabolic profile of visual cortex in diabetic rats measured with <i>in vivo<\/i> proton MRS"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5164-7216","authenticated-orcid":false,"given":"Shuang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, the Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology  Wuhan 430014 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinghua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Union Hospital, Tongji Medical College Huazhong University of 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