{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:45:08Z","timestamp":1761007508434,"version":"build-2065373602"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T00:00:00Z","timestamp":1503619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000031","name":"Institute of Human Development, Child and Youth Health","doi-asserted-by":"publisher","award":["126790","136908"],"award-info":[{"award-number":["126790","136908"]}],"id":[{"id":"10.13039\/501100000031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>Automated analysis of diffusion tensor imaging (DTI) data is an appealing way to process large datasets in an unbiased manner. However, automation can sometimes be linked to a lack of interpretability. Two whole\u2010brain, automated and voxelwise methods exist: voxel\u2010based analysis (VBA) and tract\u2010based spatial statistics (TBSS). In VBA, the amount of smoothing has been shown to influence the results. TBSS is free of this step, but a projection procedure is introduced to correct for residual misalignments. This projection assigns the local highest fractional anisotropy (FA) value to the mean FA skeleton, which represents white matter tract centers. For both methods, the normalization procedure has a major impact. These issues are well documented in humans but, to our knowledge, not in rodents. In this study, we assessed the quality of three different registration algorithms (ANTs SyN, DTI\u2010TK and FNIRT) using study\u2010specific templates and their impact on automated analysis methods (VBA and TBSS) in a rat pup model of diffuse white matter injury presenting large unilateral deformations. VBA and TBSS results were stable and anatomically coherent across the three pipelines. For VBA, in regions around the large deformations, interpretability was limited because of the increased partial volume effect. With TBSS, two of the three pipelines found a significant decrease in axial diffusivity (AD) at the known injury site. These results demonstrate that automated voxelwise analyses can be used in an animal model with large deformations.<\/jats:p>","DOI":"10.1002\/nbm.3793","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T13:12:47Z","timestamp":1503666767000},"source":"Crossref","is-referenced-by-count":4,"title":["User\u2010independent diffusion tensor imaging analysis pipelines in a rat model presenting ventriculomegalia: A comparison study"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6313-1524","authenticated-orcid":false,"given":"Luis","family":"Akakpo","sequence":"first","affiliation":[{"name":"\u00c9cole Polytechnique de Montr\u00e9al  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5529-6983","authenticated-orcid":false,"given":"Wyston C.","family":"Pierre","sequence":"additional","affiliation":[{"name":"Sainte\u2010Justine Hospital and Research Center, Department of Pediatrics Universit\u00e9 de Montr\u00e9al  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Jin","sequence":"additional","affiliation":[{"name":"Sainte\u2010Justine Hospital and Research Center, Department of Pediatrics Universit\u00e9 de Montr\u00e9al  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8058-2685","authenticated-orcid":false,"given":"Ir\u00e8ne","family":"Londono","sequence":"additional","affiliation":[{"name":"Sainte\u2010Justine Hospital and Research Center, Department of Pediatrics Universit\u00e9 de Montr\u00e9al  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9797-3137","authenticated-orcid":false,"given":"Philippe","family":"Pouliot","sequence":"additional","affiliation":[{"name":"\u00c9cole Polytechnique de Montr\u00e9al  Montreal QC Canada"},{"name":"Montreal Heart Institute  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8431-4979","authenticated-orcid":false,"given":"Gregory A.","family":"Lodygensky","sequence":"additional","affiliation":[{"name":"Sainte\u2010Justine Hospital and Research Center, Department of Pediatrics Universit\u00e9 de Montr\u00e9al  Montreal QC Canada"},{"name":"Montreal Heart Institute  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1994.1037"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1996.0086"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.01.028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1697"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0770"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.04.036"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.013"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2010.06.027"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.06.021"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.05.055"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045996"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.03.026"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1700"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0299-0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.12.015"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4520-12.2013"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13122458"},{"issue":"6","key":"e_1_2_8_21_1","article-title":"Progressive volume loss and white matter degeneration in cstb\u2010deficient mice: a diffusion tensor and longitudinal volumetry MRI study","volume":"9","author":"Manninen O","year":"2014","journal-title":"PLoS One"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124885"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.03.012"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.12.037"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2007.906784"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.01.038"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.08.008"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02545-9"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(02)00606-5"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1201\/b10500"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.242"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2006.06.004"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20965"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.963816"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.09.062"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_2_8_37_1","unstructured":"AnderssonJL JenkinsonM SmithS.Non\u2010linear registration aka Spatial normalisation FMRIB technical report TR07JA2.FMRIB Anal Group Univ Oxford.2007;2:XX."},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.101"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1058"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.060"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1148"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22211"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(99)00088-0"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20848"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnbm.3793","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.3793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:54:18Z","timestamp":1760968458000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.3793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,25]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/nbm.3793"],"URL":"https:\/\/doi.org\/10.1002\/nbm.3793","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"type":"print","value":"0952-3480"},{"type":"electronic","value":"1099-1492"}],"subject":[],"published":{"date-parts":[[2017,8,25]]},"article-number":"e3793"}}