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The assessment of bioenergetic impairment in different brain regions is essential to understand the pathophysiology and progression of human brain diseases. This article presents a simple and effective approach which allows the interleaved measurement of <jats:sup>31<\/jats:sup>P spectra and imaging from two distinct human brain regions of interest with dynamic <jats:italic>B<\/jats:italic><jats:sub>0<\/jats:sub> shimming capability. A transistor\u2013transistor logic controller was employed to actively switch the single\u2010channel X\u2010nuclear radiofrequency (RF) transmitter\u2013receiver between two <jats:sup>31<\/jats:sup>P RF surface coils, enabling the interleaved acquisition of two <jats:sup>31<\/jats:sup>P free induction decays (FIDs) from human occipital and frontal lobes within the same repetition time. Linear gradients were incorporated into the RF pulse sequence to perform the first\u2010order dynamic shimming to further improve spectral resolution. The overall results demonstrate that the approach provides a cost\u2010effective and time\u2010efficient solution for reliable <jats:sup>31<\/jats:sup>P MRS measurement of cerebral phosphate metabolites and adenosine triphosphate (ATP) metabolic fluxes from two human brain regions with high detection sensitivity and spectral quality at 7\u00a0T. The same design concept can be extended to acquire multiple spectra from more than two brain regions or can be employed for other magnetic resonance applications beyond the <jats:sup>31<\/jats:sup>P spin.<\/jats:p>","DOI":"10.1002\/nbm.3842","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T19:32:38Z","timestamp":1509046358000},"source":"Crossref","is-referenced-by-count":13,"title":["Interleaved <sup>31<\/sup>P MRS imaging of human frontal and occipital lobes using dual RF coils in combination with single\u2010channel transmitter\u2013receiver and dynamic <i>B<\/i><sub>0<\/sub> shimming"],"prefix":"10.1002","volume":"31","author":[{"given":"Byeong\u2010Yeul","family":"Lee","sequence":"first","affiliation":[{"name":"Center for Magnetic Resonance Research, Department of Radiology University of Minnesota Medical School  Minneapolis MN 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