{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:33:38Z","timestamp":1791268418064,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T00:00:00Z","timestamp":1511222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["BM1103"],"award-info":[{"award-number":["BM1103"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["016.160.351"],"award-info":[{"award-number":["016.160.351"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["864.13.014"],"award-info":[{"award-number":["864.13.014"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>The cerebral blood flow (CBF) is a potential biomarker for neurological disease. However, the arterial transit time (ATT) of the labeled blood is known to potentially affect CBF quantification. Furthermore, ATT could be an interesting biomarker in itself, as it may reflect underlying macro\u2010 and microvascular pathologies. Currently, no optimized magnetic resonance imaging (MRI) sequence exists to measure ATT in mice. Recently, time\u2010encoded labeling schemes have been implemented in rats and humans, enabling ATT mapping with higher signal\u2010to\u2010noise ratio (SNR) and shorter scan time than multi\u2010delay arterial spin labeling (ASL). In this study, we show that time\u2010encoded pseudo\u2010continuous arterial spin labeling (te\u2010pCASL) also enables transit time measurements in mice. As an optimal design that takes the fast blood flow in mice into account, time encoding with 11 sub\u2010boli of 50\u00a0ms is proposed to accurately probe the inflow of labeled blood. For perfusion imaging, a separate, traditional pCASL scan was employed. From the six studied brain regions, the hippocampus showed the shortest ATT (169\u00a0\u00b1\u00a011\u00a0ms) and the auditory\/visual cortex showed the longest (284\u00a0\u00b1\u00a016\u00a0ms). Furthermore, ATT was found to be preserved in old wild\u2010type mice. In a mouse with an induced carotid artery occlusion, prolongation of ATT was shown. In conclusion, this study shows the successful implementation of te\u2010pCASL in mice, making it possible, for the first time, to measure ATT in mice in a time\u2010efficient manner.<\/jats:p>","DOI":"10.1002\/nbm.3855","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T09:46:44Z","timestamp":1511257604000},"source":"Crossref","is-referenced-by-count":46,"title":["Transit time mapping in the mouse brain using time\u2010encoded pCASL"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2379-0861","authenticated-orcid":false,"given":"Lydiane","family":"Hirschler","sequence":"first","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, Grenoble Institut des Neurosciences  Grenoble France"},{"name":"Inserm, U1216  Grenoble France"},{"name":"Bruker Biospin  Ettlingen Germany"},{"name":"Department of Radiology, C. J. 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