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Single\u2010shot echo planar imaging (EPI) is the most common technique for DWI applications in the brain, but is prone to geometric distortions and signal voids. Rapid acquisition with relaxation enhancement [RARE, also known as fast spin echo (FSE)] imaging presents a valuable alternative to DWI with high anatomical accuracy. This work proposes a multi\u2010shot diffusion\u2010weighted RARE\u2010EPI hybrid pulse sequence, combining the anatomical integrity of RARE with the imaging speed and radiofrequency (RF) power deposition advantage of EPI. The anatomical integrity of RARE\u2010EPI was demonstrated and quantified by center of gravity analysis for both morphological images and diffusion\u2010weighted acquisitions in phantom and <jats:italic>in vivo<\/jats:italic> experiments at 3.0\u00a0T and 7.0\u00a0T. The results indicate that half of the RARE echoes in the echo train can be replaced by EPI echoes whilst maintaining anatomical accuracy. The reduced RF power deposition of RARE\u2010EPI enabled multiband RF pulses facilitating simultaneous multi\u2010slice imaging. This study shows that diffusion\u2010weighted RARE\u2010EPI has the capability to acquire high fidelity, distortion\u2010free images of the eye and the orbit. It is shown that RARE\u2010EPI maintains the immunity to <jats:italic>B<\/jats:italic><jats:sub>0<\/jats:sub> inhomogeneities reported for RARE imaging. This benefit can be exploited for the assessment of ocular masses and pathological changes of the eye and the orbit.<\/jats:p>","DOI":"10.1002\/nbm.3872","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T07:27:41Z","timestamp":1515569261000},"source":"Crossref","is-referenced-by-count":18,"title":["Multiband diffusion\u2010weighted MRI of the eye and orbit free of geometric distortions using a RARE\u2010EPI hybrid"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3567-1798","authenticated-orcid":false,"given":"Katharina","family":"Paul","sequence":"first","affiliation":[{"name":"Berlin Ultrahigh Field Facility (B.U.F.F.) Max Delbrueck Center for Molecular Medicine in the Helmholtz Association  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Huelnhagen","sequence":"additional","affiliation":[{"name":"Berlin Ultrahigh Field Facility (B.U.F.F.) 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