{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:18:27Z","timestamp":1781187507418,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"France Life Imaging","award":["ANR-11-INBS-0006"],"award-info":[{"award-number":["ANR-11-INBS-0006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>Murine radiation\u2010induced rectocolitis is considered to be a relevant animal model of gastrointestinal inflammation. The purpose of our study was to compare quantitative MRI and histopathological features in this gastrointestinal inflammation model.<\/jats:p><jats:p>Radiation rectocolitis was induced by localized single\u2010dose radiation (27\u00a0Gy) in Sprague\u2010Dawley rats. <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010weighted, <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010weighted and diffusion\u2010weighted MRI was performed at 7\u00a0T in 16 rats between 2 and 4\u00a0weeks after irradiation and in 10 control rats. Rats were sacrificed and the histopathological inflammation score of the colorectal samples was assessed.<\/jats:p><jats:p>The irradiated rats showed significant increase in colorectal wall thickness (2.1 \u00b1 0.3\u00a0mm versus 0.8 \u00b1 0.3\u00a0mm in control rats, <jats:italic>P<\/jats:italic> &lt; 0.0001), normalized <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> signal intensity (4 \u00b1 0.8 versus 2 \u00b1 0.4\u00a0AU, <jats:italic>P<\/jats:italic> &lt; 0.0001), normalized <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> signal intensity (1.4 \u00b1 0.1 versus 1.1 \u00b1 0.2\u00a0AU, <jats:italic>P<\/jats:italic> = 0.0009) and apparent and pure diffusion coefficients (ADC and <jats:italic>D<\/jats:italic>) (2.06 \u00d7 10<jats:sup>\u22123<\/jats:sup> \u00b1 0.34 versus 1.51 \u00d7 10<jats:sup>\u22123<\/jats:sup> \u00b1 0.23\u00a0mm<jats:sup>2<\/jats:sup>\/s, <jats:italic>P<\/jats:italic> = 0.0004, and 1.97 \u00d7 10<jats:sup>\u22123<\/jats:sup> \u00b1 0.43\u00a0mm<jats:sup>2<\/jats:sup>\/s versus 1.48 \u00d7 10<jats:sup>\u22123<\/jats:sup> \u00b1 0.29\u00a0mm<jats:sup>2<\/jats:sup>\/s, <jats:italic>P<\/jats:italic> = 0.008, respectively). Colorectal wall thickness (<jats:italic>r<\/jats:italic> = 0.84, <jats:italic>P<\/jats:italic> &lt; 0.0001), normalized <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> signal intensity (<jats:italic>r<\/jats:italic> = 0.85, <jats:italic>P<\/jats:italic> &lt; 0.0001) and ADC (<jats:italic>r<\/jats:italic> = 0.80, <jats:italic>P<\/jats:italic> &lt; 0.0001) were strongly correlated with the histopathological inflammation score, whereas normalized <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> signal intensity and <jats:italic>D<\/jats:italic> were moderately correlated (<jats:italic>r<\/jats:italic> = 0.64, <jats:italic>P<\/jats:italic> = 0.0006, and <jats:italic>r<\/jats:italic> = 0.65, <jats:italic>P<\/jats:italic> = 0.0003, respectively).<\/jats:p><jats:p>High\u2010field MRI features of single\u2010dose radiation\u2010induced rectocolitis in rats differ significantly from those of control rats. Quantitative MRI characteristics, especially wall thickness, normalized <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> signal intensity, ADC and <jats:italic>D<\/jats:italic>, are potential markers of the histopathological inflammation score.<\/jats:p>","DOI":"10.1002\/nbm.3897","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T02:33:59Z","timestamp":1517884439000},"source":"Crossref","is-referenced-by-count":11,"title":["Quantitative MRI in murine radiation\u2010induced rectocolitis: comparison with histopathological inflammation score"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3283-8268","authenticated-orcid":false,"given":"Magaly","family":"Zappa","sequence":"first","affiliation":[{"name":"H\u00f4pitaux Universitaires Beaujon, Radiology Universit\u00e9 Paris VII  Clichy France"},{"name":"Laboratory of Imaging Biomarkers, Center of Research on Inflammation, UMR 1149, INSERM University 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