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In this study, we examined time\u2010dependent diffusion kurtosis contrast in adult mouse brains and in neonatal mouse brains after hypoxic\u2013ischemic (HI) injury. <jats:italic>In vivo<\/jats:italic> diffusion kurtosis maps were acquired with a short diffusion time using an oscillating gradient spin echo (OGSE) sequence at 100\u00a0Hz and with a relatively long diffusion time (20\u00a0ms) using a pulsed gradient spin echo (PGSE) sequence. In the adult mouse brain, we found that the cortex and hippocampus showed larger differences between OGSE kurtosis and PGSE kurtosis than major white matter tracts. In neonatal mouse brains with unilateral HI injury, the OGSE kurtosis map overall provided stronger edema contrast than the PGSE kurtosis map, and the differences between OGSE and PGSE kurtosis measurements in the edema region reflected heterogeneity of injury. This is the first <jats:italic>in vivo<\/jats:italic> study that has demonstrated multi\u2010direction OGSE kurtosis contrasts in the mouse brain. Comparing PGSE and OGSE kurtosis measures may provide additional information on microstructural changes after ischemic stroke.<\/jats:p>","DOI":"10.1002\/nbm.3917","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T10:32:08Z","timestamp":1522405928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Oscillating gradient diffusion kurtosis imaging of normal and injured mouse brains"],"prefix":"10.1002","volume":"31","author":[{"given":"Dan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Radiology Johns Hopkins University School of Medicine  Baltimore USA"},{"name":"Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science Zhejiang University  Hangzhou 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