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Fast spin\u2010echo images weighted by chemical exchange saturation transfer (CEST) effects were collected on Sprague\u2013Dawley rats at 21.1\u00a0T, focusing on two neurological models. One involved a middle cerebral artery occlusion emulating ischemic stroke; the other involved xenografted glioma cells that were followed over the course of several days as they developed into brain tumors. A remarkably strong saturation\u2010derived contrast was observed for the growing tumors when calculating magnetization transfer ratios at <jats:italic>c<\/jats:italic>. 3.8\u00a0ppm. This large contrast originated partially from an increase in the contribution of the amide CEST effect, but mostly from strong decreases in the Overhauser and magnetization transfer contributions to the upfield region, whose differential attenuations could be clearly discerned thanks to the ultrahigh field. The high spectral separation arising at 21.1\u00a0T also revealed numerous CEST signals usually overlapping at lower fields. Ischemic lesions were also investigated but, remarkably, magnetization and saturation transfer contrasts were nearly absent when computing transfer asymmetries using either high or low saturation power schemes. These behaviors were consistently observed at 24\u00a0hours post\u2010occlusion, regardless of the data processing approach assayed. Considerations related to how various parameters defining these experiments depend on the magnetic field, primarily chemical shifts and <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> values, are discussed.<\/jats:p>","DOI":"10.1002\/nbm.3995","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T10:59:01Z","timestamp":1532689141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Brain investigations of rodent disease models by chemical exchange saturation transfer at 21.1\u2009T"],"prefix":"10.1002","volume":"31","author":[{"given":"Tangi","family":"Roussel","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Physics Weizmann Institute of Science  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens T.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"National High Magnetic Field Laboratory  Tallahassee Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7738-168X","authenticated-orcid":false,"given":"Samuel C.","family":"Grant","sequence":"additional","affiliation":[{"name":"National High Magnetic Field Laboratory  Tallahassee Florida"},{"name":"Department of Chemical &amp; Biomedical Engineering, FAMU\u2010FSU College of Engineering The Florida State University  Tallahassee Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8208-3521","authenticated-orcid":false,"given":"Lucio","family":"Frydman","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Physics Weizmann Institute of Science  Rehovot Israel"},{"name":"National High Magnetic Field Laboratory  Tallahassee Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910100113"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1492(200005)13:3<116::AID-NBM616>3.0.CO;2-D"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1999.1956"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200011)44:5<799::AID-MRM18>3.0.CO;2-S"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2012.11.024"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/58\/22\/R221"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781315364421"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2586(200011)12:5<745::AID-JMRI12>3.0.CO;2-H"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2615"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3252"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3436"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.12"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10651"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm907"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24315"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25277"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21873"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24560"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20818"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2011.05.001"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22761"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24664"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-0825"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21122"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.149"},{"key":"e_1_2_8_27_1","unstructured":"CornnellHH GrantSC RosenbergJT et al.Characterization of paramagnetic lanthanide ion complexes as MRI contrast agents as a function of magnetic field strength. 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