{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:42:16Z","timestamp":1760985736300,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000147","name":"Canadian Breast Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>The glycerol methylene proton resonances (4\u20134.5 parts per million, ppm), which arise from the triglyceride backbone, are relevant to fat composition assessment and can be measured with proton MRS. The purpose of the presented work is to determine long TE (echo time) point resolved spectroscopy (PRESS) and stimulated echo acquisition mode (STEAM) values at 3\u00a0T to resolve the glycerol resonances from that of overlapping water. The response of the glycerol methylene protons of nine edible oils as a function of PRESS and STEAM TE (mixing time, TM\u00a0=\u00a020\u00a0ms) was investigated. In addition, high resolution NMR spectra of the oils were acquired at 16.5\u00a0T. Long TE values where <jats:italic>J<\/jats:italic>\u2010coupling losses were lowest were selected, namely a TE of 180\u00a0ms for PRESS (first echo time 17\u00a0ms) and a TE of 100\u00a0ms for STEAM (mixing time 20\u00a0ms). Oil olefinic (\u22485.4\u00a0ppm) to glycerol ratios were calculated from the long TE spectra and correlated with 16.5\u00a0T ratios. The two techniques yielded olefinic\/glycerol ratios that correlated with 16.5\u00a0T ratios (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.79 for PRESS and 0.90 for STEAM). The efficacy of the sequences in resolving the glycerol resonance from that of water was verified in vivo on tibial bone marrow of four healthy volunteers. In addition, the potential for using the glycerol methylene signal normalized to the methyl signal (\u22480.9\u00a0ppm) to assess changes in free fatty acid content was demonstrated by measuring differences in spectra acquired from a triglyceride peanut oil phantom and from a phantom composed of a mixture of peanut oil and free fatty acid oleic acid.<\/jats:p>","DOI":"10.1002\/nbm.4021","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T12:11:29Z","timestamp":1540901489000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long TE PRESS and STEAM for measuring the triglyceride glycerol CH<sub>2<\/sub> protons at 3\u00a0T"],"prefix":"10.1002","volume":"32","author":[{"given":"Logan","family":"Fairgrieve\u2010Park","sequence":"first","affiliation":[{"name":"Department of Oncology University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara J.","family":"Fallone","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7189-672X","authenticated-orcid":false,"given":"Atiyah","family":"Yahya","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Alberta  Edmonton Alberta Canada"},{"name":"Department of Medical Physics Cross Cancer Institute  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21335"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22820"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2849"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20367"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24510"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24532"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25920"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23868"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1483"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.2629"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2005.09.006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-4-24"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)40456-0"},{"issue":"480","key":"e_1_2_8_15_1","first-page":"228","article-title":"inventor. 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