{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:08:46Z","timestamp":1784264926105,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Little attention has been paid to relating MRS outputs of vendor\u2010supplied platforms to those from research software. This comparison is crucial to advance MRS as a clinical prognostic tool for disease or injury, recovery, and outcome.<\/jats:p><jats:p>The work presented here investigates the agreement between metabolic ratios reported from vendor\u2010provided and LCModel fitting algorithms using MRS data obtained on Siemens 3\u00a0T TIM Trio and 3\u00a0T Skyra MRI scanners in a total of 55 premature infants and term neonates with hypoxic ischemic encephalopathy (HIE). We compared peak area ratios in single voxels placed in basal ganglia (BG) and frontal white matter (WM) using standard PRESS (TE\u00a0=\u00a030\u00a0ms and 270\u00a0ms) and STEAM (TE\u00a0=\u00a020\u00a0ms) MRS sequences at multiple times after birth from 5 to 60\u00a0days.<\/jats:p><jats:p>A total of 74 scans met quality standards for inclusion, reflecting a spectrum of neonatal disease and several months of early infant development. For the long TE PRESS sequence, N\u2010acetylaspartate (NAA) and Choline (Cho) ratios to Creatine (Cr) correlated strongly between LCModel and vendor\u2010supplied software in the BG. For shorter TEs, the ratios of NAA\/Cr and Cho\/Cr were more closely related using STEAM at TE\u00a0=\u00a020\u00a0ms in BG and WM, which was significantly better than using PRESS at TE\u00a0=\u00a030\u00a0ms in the BG of HIE infants.<\/jats:p><jats:p>At short TEs, however, it is still unclear which MRS sequence, STEAM or PRESS, is superior and thus more work is required in this regard for translating research\u2010generated MRS ratios to clinical diagnosis and prognostication, and unlocking the potential of MRS for in vivo metabolomics. MRS at both long and short TEs is desirable for standard metabolites such as NAA, Cho and Cr, along with important lower concentration metabolites such as myo\u2010inositol and glutathione.<\/jats:p>","DOI":"10.1002\/nbm.4089","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T06:59:11Z","timestamp":1553842751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Identifying the translational complexity of magnetic resonance spectroscopy in neonates and infants"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8262-804X","authenticated-orcid":false,"given":"Hunter G.","family":"Moss","sequence":"first","affiliation":[{"name":"Department of Radiology Medical University of South Carolina  Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothea D.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical University of South Carolina  Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milad","family":"Yazdani","sequence":"additional","affiliation":[{"name":"Department of Radiology Medical University of South Carolina  Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truman R.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Radiology Medical University of South Carolina  Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1046"},{"issue":"7","key":"e_1_2_9_3_1","first-page":"1546","article-title":"Proton MR spectroscopy in neonates with perinatal cerebral hypoxic\u2013ischemic injury: metabolite peak\u2010area ratios, relaxation times, and absolute concentrations","volume":"27","author":"Cheong JL","year":"2006","journal-title":"AJNR Am J Neuroradiol."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110213"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.10.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13122679"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6565(97)00014-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1492(200002)13:1<28::AID-NBM606>3.0.CO;2-L"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910300604"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.698"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1179\/174313209X395481"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.697"},{"key":"e_1_2_9_13_1","unstructured":"ChuZ WangZJ ChiaJ HunterJV.Comparison of Quantification of Clinical MR Spectra by LCModel and the Scanner System Software. Paper presented at Proceedings of the International Society of Magnetic Resonance in Medicine 2007 Berlin Germany."},{"key":"e_1_2_9_14_1","unstructured":"SoherBJ SemanchukP ToddD SteinbergJ YoungK.Vespa: Integrated applications for RF pulse design spectral simulation and MRS data analysis. Paper presented at Proceedings of the International Society of Magnetic Resonance in Medicine2011 Quebec Canada."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18765828"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-013-1199-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.69"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2015.121"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26144"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.891"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2007.08.027"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738040190110501"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2011.40"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.mp.2015-0041"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085829"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2016.10.006"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910300405"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-008912"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00347-6"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-14-111"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.4089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nbm.4089","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.4089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:50:07Z","timestamp":1760950207000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.4089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,29]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/nbm.4089"],"URL":"https:\/\/doi.org\/10.1002\/nbm.4089","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,29]]},"assertion":[{"value":"2018-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e4089"}}