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Some extracted model parameters are more sensitive to demyelination, such as the bound pool fraction (f) in quantitative magnetization transfer imaging (qMTI), the radial diffusivity in diffusion tensor imaging (DTI), and the myelin water fraction (MWF) in myelin water imaging (MWI). A 3D ultrashort echo time (UTE) sequence within an appropriate water suppression condition (Diff\u2010UTE) is also considered for the direct visualization of the myelin semi\u2010solid matrix (Diff\u2010UTE normalized signal; rSPF). In this paper, we aimed at assessing the sensitivities and correlations of the parameters mentioned above to an immuno\u2010histological study of the myelin basic protein (MBP) in a murine model of demyelination at 7\u00a0T. We demonstrated a high sensitivity of the MRI metrics to demyelination, and strong Spearman correlations in the corpus callosum between histology, macromolecular proton fraction (<jats:italic>\u03c1<\/jats:italic>&gt;0.87) and Diff\u2010UTE signal (<jats:italic>\u03c1<\/jats:italic>&gt;0.76), but moderate ones with radial diffusivity and MWF (|<jats:italic>\u03c1<\/jats:italic>|&lt;0.70).<\/jats:p>","DOI":"10.1002\/nbm.4116","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T08:23:53Z","timestamp":1561105433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Correlations of quantitative MRI metrics with myelin basic protein (MBP) staining in a murine model of demyelination"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4688-3262","authenticated-orcid":false,"given":"Lucas","family":"Soustelle","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Strasbourg, CNRS, ICube, FMTS  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Antal","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, CNRS, ICube, FMTS  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Lamy","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, CNRS, ICube, FMTS  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Institut Mines T\u00e9l\u00e9com Atlantique, INSERM, LaTIM  Brest 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