{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:05:32Z","timestamp":1790892332402,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471721"],"award-info":[{"award-number":["81471721"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471722"],"award-info":[{"award-number":["81471722"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81641169"],"award-info":[{"award-number":["81641169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771887"],"award-info":[{"award-number":["81771887"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771897"],"award-info":[{"award-number":["81771897"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004602","name":"Program for New Century Excellent Talents in University","doi-asserted-by":"publisher","award":["NCET\u201013\u20100386"],"award-info":[{"award-number":["NCET\u201013\u20100386"]}],"id":[{"id":"10.13039\/501100004602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2019YJ00879"],"award-info":[{"award-number":["2019YJ00879"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>We developed a novel manganese (Mn<jats:sup>2+<\/jats:sup>) chelate for magnetic resonance imaging (MRI) assessment of myocardial viability in acute and chronic myocardial infarct (MI) models, and compared it with Gadolinium\u2010based delay enhancement MRI (Gd<jats:sup>3+<\/jats:sup>\u2010DEMRI) and histology. MI was induced in 14 rabbits by permanent occlusion of the left circumflex coronary artery. Gd<jats:sup>3+<\/jats:sup>\u2010DEMRI and Mn<jats:sup>2+<\/jats:sup> chelate\u2010based delayed enhancement MRI (Mn<jats:sup>2+<\/jats:sup> chelate\u2010DEMRI) were performed at 7\u00a0days (acute MI, <jats:italic>n<\/jats:italic>\u00a0=\u00a08) or 8\u00a0weeks (chronic MI, <jats:italic>n<\/jats:italic>\u00a0=\u00a06) after surgery with sequential injection of 0.15\u00a0mmol\/kg Gd<jats:sup>3+<\/jats:sup> and Mn<jats:sup>2+<\/jats:sup> chelate. The biodistribution of Mn<jats:sup>2+<\/jats:sup> in tissues and blood was measured at 1.5 and 24\u00a0h. Blood pressure, heart rate (HR), left ventricular (LV) function, and infarct fraction (IF) were analyzed, and IF was compared with the histology. The Mn<jats:sup>2+<\/jats:sup> chelate group maintained a stable hemodynamic status during experiment. For acute and chronic MI, all rabbits survived without significant differences in HR or LV function before and after injection of Mn<jats:sup>2+<\/jats:sup> chelate or Gd<jats:sup>3+<\/jats:sup> (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). Mn<jats:sup>2+<\/jats:sup> chelate mainly accumulated in the kidney, liver, spleen, and heart at 1.5\u00a0h, with low tissue uptake and urine residue at 24\u00a0h after injection. In the acute MI group, there was no significant difference in IF between Mn<jats:sup>2+<\/jats:sup> chelate\u2010DEMRI and histology (22.92\u00a0\u00b1\u00a02.21% vs. 21.79\u00a0\u00b1\u00a02.25%, respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.87), while Gd<jats:sup>3+<\/jats:sup>\u2010DEMRI overestimated IF, as compared with histology (24.54\u00a0\u00b1\u00a01.73%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). In the chronic MI group, there was no significant difference in IF between the Mn<jats:sup>2+<\/jats:sup> chelate\u2010DEMRI, Gd<jats:sup>3+<\/jats:sup>\u2010DEMRI, and histology (29.50\u00a0\u00b1\u00a011.39%, 29.95\u00a0\u00b1\u00a09.40%, and 29.00\u00a0\u00b1\u00a010.44%, respectively, <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05), and all three were well correlated (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.92\u20130.96, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). We conclude that the use of Mn<jats:sup>2+<\/jats:sup> chelate\u2010DEMRI is reliable for MI visualization and identifies acute MI more accurately than Gd<jats:sup>3+<\/jats:sup>\u2010DEMRI.<\/jats:p>","DOI":"10.1002\/nbm.4158","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T09:29:26Z","timestamp":1565256566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Accurate identification of myocardial viability after myocardial infarction with novel manganese chelate\u2010based MR imaging"],"prefix":"10.1002","volume":"32","author":[{"given":"Ling\u2010yi","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital, Sichuan University  20# Section 3 South Renmin Road Chengdu 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Related Diseases of Women and Children of Ministry of Education West China Second University Hospital, Sichuan University  20# Section 3 South Renmin Road Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010qiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Sichuan Key Laboratory of Medical Imaging and School of Medical Imaging North Sichuan Medical College  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Sichuan University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010ming","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science Northwest University  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