{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:42Z","timestamp":1786978242057,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17PRE33370103"],"award-info":[{"award-number":["17PRE33370103"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["R\u2010AD\u20101409\u201020772"],"award-info":[{"award-number":["R\u2010AD\u20101409\u201020772"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n                    Assessing brain temperature can provide important information about disease processes (e.g., stroke, trauma) and therapeutic effects (e.g., cerebral hypothermia treatment). Whole\u2010brain magnetic resonance spectroscopic imaging (WB\u2010MRSI) is increasingly used to quantify brain metabolites across the entire brain. However, its feasibility and reliability for estimating brain temperature needs further validation. Therefore, the present study evaluates the reproducibility of WB\u2010MRSI for temperature mapping as well as metabolite quantification across the whole brain in healthy volunteers. Ten healthy adults were scanned on three occasions 1 week apart. Brain temperature, along with four commonly assessed brain metabolites\u2014total\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl\u2010aspartate (tNAA), total creatine (tCr), total choline (tCho) and myo\u2010inositol (mI)\u2014were measured from WB\u2010MRSI data. Reproducibility was evaluated using the coefficient of variation (\n                    <jats:italic>CV<\/jats:italic>\n                    ). The measured mean (range) of the intra\u2010subject\n                    <jats:italic>CV<\/jats:italic>\n                    s was 0.9% (0.6%\u20101.6%) for brain temperature mapping, and 4.7% (2.5%\u201015.7%), 6.4% (2.4%\u201018.9%) and 14.2% (4.4%\u201052.6%) for tNAA, tCho and mI, respectively, with reference to tCr. Consistently larger variability was found when using H\n                    <jats:sub>2<\/jats:sub>\n                    O as the reference for metabolite quantifications: 7.8% (3.3%\u201017.8%), 7.8% (3.1%\u201018.0%), 9.8% (3.7%\u201031.0%) and 17.0% (5.9%\u201054.0%) for tNAA, tCr, tCho and mI, respectively. Further, the larger the brain region (indicated by a greater number of voxels within that region), the better the reproducibility for both temperature and metabolite estimates. Our results demonstrate good reproducibility of whole\u2010brain temperature and metabolite measurements using the WB\u2010MRSI technique.\n                  <\/jats:p>","DOI":"10.1002\/nbm.4313","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T10:11:08Z","timestamp":1588155068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Reproducibility of whole\u2010brain temperature mapping and metabolite quantification using proton magnetic resonance spectroscopy"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2868-9941","authenticated-orcid":false,"given":"Yue","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Psychology University of Alabama at Birmingham  Alabama US"},{"name":"Department of Neurosurgery and Core for Advanced MRI Baylor College of Medicine  Houston Texas US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Taub","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Alabama at Birmingham  Alabama US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Alabama at Birmingham  Alabama US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarred","family":"Younger","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Alabama at Birmingham  Alabama US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitendra","family":"Uswatte","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Alabama at Birmingham  Alabama US"},{"name":"Department of Physical Therapy University of Alabama at Birmingham  Alabama US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5774-2297","authenticated-orcid":false,"given":"Thomas Patrick","family":"DeRamus","sequence":"additional","affiliation":[{"name":"TReNDs Center for Translational Research in Neuroimaging and Data Science  Georgia US"},{"name":"Department of Psychology Georgia State University  Georgia US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Knight","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Alabama at Birmingham  Alabama US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1258\/0007142001903256"},{"issue":"2","key":"e_1_2_9_3_1","first-page":"221","article-title":"Nuclear medicine in the rehabilitative treatment evaluation in stroke recovery. 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