{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:41:07Z","timestamp":1772808067181,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:00:00Z","timestamp":1592697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006098","name":"Radiological Society of North America","doi-asserted-by":"publisher","award":["RSNA Resident Grant (PI: Allen)"],"award-info":[{"award-number":["RSNA Resident Grant (PI: Allen)"]}],"id":[{"id":"10.13039\/100006098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Doxorubicin and doxorubicin\u2010trastuzumab combination chemotherapy have been associated with cardiotoxicity that eventually leads to heart failure and may limit dose\u2010effective cancer treatment. Current diagnostic strategies rely on decreased ejection fraction (EF) to diagnose cardiotoxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study is to explore the potential of cardiac MR (CMR) imaging to identify imaging biomarkers in a mouse model of chemotherapy\u2010induced cardiotoxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cumulative dose of 25 mg\/kg doxorubicin was administered over three weeks using subcutaneous pellets (<jats:italic>n<\/jats:italic> = 9, Dox). Another group (n = 9) received same dose of Dox and a total of 10 mg\/kg trastuzumab (DT). Mice were imaged at baseline, 5\/6 weeks and 10 weeks post\u2010treatment on a 7T MRI system. The protocol included short\u2010axis cine MRI covering the left ventricle (LV) and mid\u2010ventricular short\u2010axis tissue phase mapping (TPM), pre\u2010 and post\u2010contrast T1 mapping, T2 mapping and Displacement Encoding with Stimulated Echoes (DENSE) strain encoded MRI. EF, peak myocardial velocities, native T1, T2, extracellular volume (ECV), and myocardial strain were quantified. <jats:italic>N<\/jats:italic> = 7 mice were sacrificed for histopathologic assessment of apoptosis at 5\/6 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Global peak systolic longitudinal velocity was reduced at 5\/6 weeks in Dox (0.6 \u00b1 0.3 vs 0.9 \u00b1 0.3, <jats:italic>p<\/jats:italic> = 0.02). In the Dox group, native T1 was reduced at 5\/6 weeks (1.3 \u00b1 0.2 ms vs 1.6 \u00b1 0.2 ms, p = 0.02), and relatively normalized at week 10 (1.4 \u00b1 0.1 ms vs 1.6 \u00b1 0.2 ms, <jats:italic>p<\/jats:italic> &gt; 0.99). There was no change in EF and other MRI parameters and histopathologic results demonstrated minimal apoptosis in all mice (~1\u20132 apoptotic cell\/high power field), suggesting early\u2010stage cardiotoxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a mouse model of chemotherapy\u2010induced cardiotoxicity using doxorubicin and trastuzumab, advanced CMR shows promise in identifying treatment\u2010related decrease in myocardial velocity and native T1 prior to the onset of cardiomyocyte apoptosis and reduction of EF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nbm.4327","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T01:27:14Z","timestamp":1592789234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cardiac MRI Myocardial Functional and Tissue Characterization Detects Early Cardiac Dysfunction in a Mouse Model of Chemotherapy\u2010Induced Cardiotoxicity"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3659-2151","authenticated-orcid":false,"given":"Nivedita K.","family":"Naresh","sequence":"first","affiliation":[{"name":"Department of Radiology Northwestern University  737 N. 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