{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:58:09Z","timestamp":1792166289449,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T00:00:00Z","timestamp":1595030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004243","name":"Prinses Beatrix Spierfonds","doi-asserted-by":"publisher","award":["W.OR16\u201006"],"award-info":[{"award-number":["W.OR16\u201006"]}],"id":[{"id":"10.13039\/501100004243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>The aim of this study was to document upper leg involvement in spinal muscular atrophy (SMA) with quantitative MRI (qMRI) in a cross\u2010sectional cohort of patients of varying type, disease severity and age. Thirty\u2010one patients with SMA types 2 and 3 (aged 29.6 [7.6\u201073.9] years) and 20 healthy controls (aged 37.9 [17.7\u201071.6] years) were evaluated in a 3 T MRI with a protocol consisting of DIXON, T2 mapping and diffusion tensor imaging (DTI). qMRI measures were compared with clinical scores of motor function (Hammersmith Functional Motor Scale Expanded [HFMSE]) and muscle strength. Patients exhibited an increased fat fraction and fractional anisotropy (FA), and decreased mean diffusivity (MD) and T2 compared with controls (all <jats:italic>P<\/jats:italic> &lt; .001). DTI parameters FA and MD manifest stronger effects than can be accounted for the effect of fatty replacement. Fat fraction, FA and MD show moderate correlation with muscle strength and motor function: FA is negatively associated with HFMSE and Medical Research Council sum score (\u03c4 = \u22120.56 and \u22120.59; both <jats:italic>P<\/jats:italic> &lt; .001) whereas for fat fraction values are \u03c4 = \u22120.50 and \u22120.58, respectively (both <jats:italic>P<\/jats:italic> &lt; .001). This study shows that DTI parameters correlate with muscle strength and motor function. DTI findings indirectly indicate cell atrophy and act as a measure independently of fat fraction. Combined these data suggest the potential of muscle DTI in monitoring disease progression and to study SMA pathogenesis in muscle.<\/jats:p>","DOI":"10.1002\/nbm.4357","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T03:15:55Z","timestamp":1595042155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Quantitative MRI of skeletal muscle in a cross\u2010sectional cohort of patients with spinal muscular atrophy types 2 and 3"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2998-4683","authenticated-orcid":false,"given":"Louise A.M.","family":"Otto","sequence":"first","affiliation":[{"name":"Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht Utrecht University  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W\u2010Ludo","family":"van der 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