{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:24:25Z","timestamp":1760955865163,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LQ1605 from the National Program of Sustainability","Specific University Research (MUNI\/A\/1493\/2018)"],"award-info":[{"award-number":["LQ1605 from the National Program of Sustainability","Specific University Research (MUNI\/A\/1493\/2018)"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sarcoidosis is a systemic granulomatous disease affecting in particular the respiratory tract. Cardiac magnetic resonance (CMR), including a measurement of <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> relaxation time, could potentially detect early stadia of sarcoidosis of the heart. The study aims to assess <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> mapping in the detection of early cardiac involvement in asymptomatic patients with sarcoidosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and twenty patients with extracardiac sarcoidosis and without any heart disease history were included. One hundred and thirteen of them underwent a CMR examination. The mean time from the diagnosis of sarcoidosis was 0.8 (0.2\u20103.3) years. Cine images for the assessment of left ventricular (LV) functional parameters and pre\u2010 and post\u2010contrast saturation method using adaptive recovery times for cardiac <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> mapping (SMART<jats:sub>1<\/jats:sub>Map) and modified Look\u2010Locker inversion recovery (MOLLI) images were acquired for the assessment of native <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> relaxation time and extracellular volume (ECV). The measured parameters were compared between sarcoidosis patients and 22 controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sarcoidosis patients had normal global and regional systolic LV function\u2014LV ejection fraction 65 \u00b1 5% versus 66 \u00b1 7% (<jats:italic>p<\/jats:italic> NS). The mean native <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> relaxation times were not prolonged\u20141465 \u00b1 93 ms versus 1480 \u00b1 88 ms (<jats:italic>p<\/jats:italic> NS) measured by SMART<jats:sub>1<\/jats:sub>Map and 1317 \u00b1 60 ms versus 1313 \u00b1 83 ms (<jats:italic>p<\/jats:italic> NS) measured using a MOLLI sequence. Similarly, the mean ECV values did not increase\u201416.9 \u00b1 3.9% versus 17.9 \u00b1 3.7% (<jats:italic>p<\/jats:italic> NS) measured by SMART<jats:sub>1<\/jats:sub>Map and 30.9 \u00b1 2.9% versus 31.6 \u00b1 8.3% (<jats:italic>p<\/jats:italic> NS) measured using a MOLLI sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Myocardial native <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> relaxation times were not prolonged and ECV was not increased in asymptomatic patients with extracardiac sarcoidosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nbm.4388","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T11:23:09Z","timestamp":1596540189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Myocardial <i>T<\/i><sub>1<\/sub> mapping using SMART<sub>1<\/sub>Map and MOLLI mapping in asymptomatic patients with recent extracardiac sarcoidosis"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-132X","authenticated-orcid":false,"given":"Roman","family":"Panovsk\u00fd","sequence":"first","affiliation":[{"name":"International Clinical Research Center, St. Anne's Faculty Hospital, Faculty of Medicine Masaryk University  Brno Czech Republic"},{"name":"1st Department of Internal Medicine\/Cardioangiology, St. Anne's Faculty Hospital, Faculty of Medicine Masaryk University  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Doubkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases and Tuberculosis Masaryk University Faculty of Medicine and University Hospital  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1\u0161","family":"Hole\u010dek","sequence":"additional","affiliation":[{"name":"International Clinical Research Center, St. Anne's Faculty 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