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In order to investigate the binge\u2010like eating behavior in female rats, induced by intermittent food restrictions\/refeeding and frustration stress, we analyzed for the first time the metabolic profile obtained from serum of rats, through nuclear magnetic resonance (NMR) spectroscopy. In this experimental protocol, rats were exposed to chow food restricting\/refeeding and frustration stress manipulation. This stress procedure consists of 15 min exposure to the odor and sight of a familiar chocolate paste, without access to it, just before offering the palatable food. In this model, a \u201cbinge\u2010eating episode\u201d was considered the significantly higher palatable food consumption within 2 h in restricted and stressed rats (R + S) than in the other three experimental groups: rats with no food restriction and no stress (NR + NS), only stressed rats (NR + S) or only restricted rats (R + NS). Serum samples from these four different rat groups were collected. The statistical analysis of the <jats:sup>1<\/jats:sup>H NMR spectral profiles of the four sets of samples pointed to <jats:italic>O<\/jats:italic>\u2010 and <jats:italic>N<\/jats:italic>\u2010acetyl glycoproteins as the main biomarkers for the discrimination of restriction effects. Other metabolites, such as threonine, glycine, glutamine, acetate, pyruvate and lactate, showed trends that may be useful to understand metabolic pathways involved in eating disorders. This study suggested that NMR\u2010based metabolomics is a suitable approach to detect biomarkers related to binge\u2010eating behavior.<\/jats:p>","DOI":"10.1002\/nbm.4469","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T01:18:43Z","timestamp":1610932723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum metabolic signature of binge\u2010like palatable food consumption in female rats by nuclear magnetic resonance spectroscopy"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6180-828X","authenticated-orcid":false,"given":"Carlo","family":"Cifani","sequence":"first","affiliation":[{"name":"School of Pharmacy, Pharmacology Unit University of Camerino  Camerino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2332-3166","authenticated-orcid":false,"given":"Silvia","family":"Alboni","sequence":"additional","affiliation":[{"name":"Department of Life Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3303-8761","authenticated-orcid":false,"given":"Adele","family":"Mucci","sequence":"additional","affiliation":[{"name":"Department of Chemical and Geological Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0236-9525","authenticated-orcid":false,"given":"Cristina","family":"Benatti","sequence":"additional","affiliation":[{"name":"Department of Life Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5414-2368","authenticated-orcid":false,"given":"Luca","family":"Botticelli","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Pharmacology Unit University of Camerino  Camerino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0848-4754","authenticated-orcid":false,"given":"Nicoletta","family":"Brunello","sequence":"additional","affiliation":[{"name":"Department of Life Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8044-1206","authenticated-orcid":false,"given":"Maria Vittoria","family":"Micioni Di Bonaventura","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Pharmacology Unit University of Camerino  Camerino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2394-8462","authenticated-orcid":false,"given":"Valeria","family":"Righi","sequence":"additional","affiliation":[{"name":"Department for the Quality of Life Studies University of Bologna  Rimini Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqy342"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.22"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-004-2657-y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22501"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.040"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.11.020"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2014.10.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1300\/J069v23n03_04"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.08.008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.04.022"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00545"},{"key":"e_1_2_9_14_1","unstructured":"US Food and Drug Administration.FDA expands uses of Vyvanse to treat binge\u2010eating disorder.http:\/\/wwwfdagov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm432543htm. 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