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The concomitant presence of portal vein thrombosis (PVT) implies a change in hepatic portal inflow that could also affect liver elasticity. The main objective of this study is to determine the extent to which the presence of portal occlusion can affect the mechanical properties of the liver and potentially lead to misdiagnosis of fibrosis and hepatic cirrhosis by elastography. Portal vein occlusion was generated by insertion and inflation of a balloon catheter in the portal vein of four swines. The portal flow parameters peak flow (PF) and peak velocity magnitude (PVM) and liver mechanical properties (shear modulus) were then investigated using 4D\u2010flow MRI and MR elastography, respectively, for progressive obstructions of the portal vein. Experimental results indicate that the reduction of the intrahepatic venous blood flow (PF\/PVM decreases of 29.3%\/8.5%, 51.0%\/32.3% and 83.3%\/53.6%, respectively) measured with 50%, 80% and 100% obstruction of the portal vein section results in a decrease of liver stiffness by 0.8%\u2009\u00b1\u20090.1%, 7.7%\u2009\u00b1\u20090.4% and 12.3%\u2009\u00b1\u20090.9%, respectively. While this vascular mechanism does not have sufficient influence on the elasticity of the liver to modify the diagnosis of severe fibrosis or cirrhosis (F4 METAVIR grade), it may be sufficient to attenuate the increase in stiffness due to moderate fibrosis (F2\u2010F3 METAVIR grades) and consequently lead to false\u2010negative diagnoses with elastography in the presence of PVT.<\/jats:p>","DOI":"10.1002\/nbm.4498","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T22:06:30Z","timestamp":1614290790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Influence of portal vein occlusion on portal flow and liver elasticity in an animal model"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8999-3608","authenticated-orcid":false,"given":"Simon","family":"Chatelin","sequence":"first","affiliation":[{"name":"ICube, CNRS UMR 7357 University of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-1496","authenticated-orcid":false,"given":"Raoul","family":"Pop","sequence":"additional","affiliation":[{"name":"IHU\u2010Strasbourg Institute for Image\u2010Guided Surgery  Strasbourg France"},{"name":"Interventional Neuroradiology Department University Hospital of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5075-8678","authenticated-orcid":false,"given":"C\u00e9line","family":"Giraudeau","sequence":"additional","affiliation":[{"name":"IHU\u2010Strasbourg Institute for Image\u2010Guided Surgery  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7448-8836","authenticated-orcid":false,"given":"Khalid","family":"Ambarki","sequence":"additional","affiliation":[{"name":"Siemens Healthcare SAS, Saint Denis  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Jin","sequence":"additional","affiliation":[{"name":"Siemens Medical Solutions USA, Inc.  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