{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:21:34Z","timestamp":1779204094102,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>Myocardial T1 reactivity, defined as the relative change in T1 between rest and vasodilator\u2010induced stress, has been proposed as a magnetic resonance imaging (MRI) biomarker of tissue perfusion. We hypothesize that the superparamagnetic iron\u2010oxide nanoparticle, ferumoxytol, sensitizes T1 to changes in the intramyocardial vascular compartment and improves the sensitivity and specificity of T1 reactivity as an imaging biomarker of tissue perfusion. We aim to assess the diagnostic performance of ferumoxytol\u2010enhanced (FE) myocardial T1 reactivity in swine models of myocardial hypoperfusion. We induced acute myocardial hypoperfusion in 13 swine via percutaneous, transcatheter deployment of a 3D printed intracoronary stenosis implant into the left anterior descending coronary artery. We performed native and FE adenosine stress testing using 5(3)3(3)3 MOLLI and SASHA T1 mapping sequences with bSSFP readout on a clinical 3.0 T magnet. MOLLI T1 maps were fitted using both the conventional MOLLI and the Instantaneous Signal Loss (InSiL) T1\u2010fitting algorithms. Regardless of the MOLLI or SASHA pulse sequence or T1\u2010fitting algorithm, ferumoxytol contrast increased the dynamic range of T1 reactivity in both the remote and ischemic myocardial regions. Relative to remote myocardium, native and FE T1 reactivity were blunted in ischemic myocardium (<jats:italic>p<\/jats:italic> &lt; 0.05) with InSiL\u2010MOLLI, MOLLI and SASHA. An InSiL\u2010MOLLI\u2013derived FE T1 reactivity threshold of \u22124.65% had 73.3% sensitivity and 96.2% specificity for prediction of regional wall motion abnormalities (AUC 0.915, 95% CI 0.786\u20130.979), whereas a SASHA\u2010derived FE T1 reactivity threshold of \u22125.25% had 75.0% sensitivity and 95.2% specificity (AUC 0.905, 95% CI 0.751\u20130.979). Ferumoxytol significantly increased the dynamic range of T1 reactivity as a measure of myocardial hypoperfusion in vasodilator stress T1 mapping studies. FE T1 reactivity maps can be used to quantitatively distinguish ischemic and remote myocardium with high specificity in swine models of acute myocardial hypoperfusion.<\/jats:p>","DOI":"10.1002\/nbm.4518","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T06:02:32Z","timestamp":1617861752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Ferumoxytol\u2010enhanced magnetic resonance T1 reactivity for depiction of myocardial hypoperfusion"],"prefix":"10.1002","volume":"34","author":[{"given":"Caroline M.","family":"Colbert","sequence":"first","affiliation":[{"name":"Physics and Biology in Medicine Graduate Program David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna H.","family":"Le","sequence":"additional","affiliation":[{"name":"Division of Cardiology David Geffen School of Medicine at UCLA and 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