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This review covers the literature until May 2020 centered on the early prediction of the viability of <jats:italic>in vitro<\/jats:italic> developed embryos using several analytical techniques, including NMR. Nowadays, the predominant non\u2010invasive technique for selecting viable embryos is based on morphology, where variables associated with the rate of cleavage and blastocyst formation are evaluated by the embryologist following standardized criteria that are somewhat subjective. This morphological approach is therefore inadequate for the prediction of embryo quality, and several studies have focused on developing new non\u2010invasive methods using molecular approaches based particularly on metabolomics. 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