{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:46:27Z","timestamp":1790041587295,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>\n                    COVID\u201019 is a systemic infectious disease that may affect many organs, accompanied by a measurable metabolic dysregulation. The disease is also associated with significant mortality, particularly among the elderly, patients with comorbidities, and solid organ transplant recipients. Yet, the largest segment of the patient population is asymptomatic, and most other patients develop mild to moderate symptoms after SARS\u2010CoV\u20102 infection. Here, we have used NMR metabolomics to characterize plasma samples from a cohort of the abovementioned group of COVID\u201019 patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u200969), between 3 and 10\u2009months after diagnosis, and compared them with a set of reference samples from individuals never infected by the virus (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u200971). Our results indicate that half of the patient population show abnormal metabolism including porphyrin levels and altered lipoprotein profiles six months after the infection, while the other half show little molecular record of the disease. Remarkably, most of these patients are asymptomatic or mild COVID\u201019 patients, and we hypothesize that this is due to a metabolic reflection of the immune response stress.\n                  <\/jats:p>","DOI":"10.1002\/nbm.4637","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T02:15:24Z","timestamp":1635387324000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Uneven metabolic and lipidomic profiles in recovered COVID\u201019 patients as investigated by plasma NMR metabolomics"],"prefix":"10.1002","volume":"35","author":[{"given":"Maider","family":"Bizkarguenaga","sequence":"first","affiliation":[{"name":"Precision Medicine and Metabolism Laboratory, CIC bioGUNE Basque Research and Technology Alliance  Derio Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bruzzone","sequence":"additional","affiliation":[{"name":"Precision Medicine and Metabolism Laboratory, CIC bioGUNE Basque Research and Technology Alliance  Derio Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Gil\u2010Redondo","sequence":"additional","affiliation":[{"name":"Precision Medicine and Metabolism Laboratory, CIC bioGUNE Basque Research and Technology Alliance  Derio Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itxaso","family":"SanJuan","sequence":"additional","affiliation":[{"name":"Precision Medicine and Metabolism Laboratory, CIC bioGUNE Basque Research and Technology Alliance  Derio Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"Martin\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE Basque Research and Technology Alliance  Derio Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Barriales","sequence":"additional","affiliation":[{"name":"Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE Basque Research and Technology Alliance  Derio Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainhoa","family":"Palacios","sequence":"additional","affiliation":[{"name":"Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE Basque Research and Technology Alliance  Derio Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel T.","family":"Pasco","sequence":"additional","affiliation":[{"name":"Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE Basque Research and Technology Alliance  Derio Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Gonz\u00e1lez\u2010Valle","sequence":"additional","affiliation":[{"name":"Precision Medicine and Metabolism Laboratory, CIC bioGUNE Basque Research and Technology Alliance  Derio Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"La\u00edn","sequence":"additional","affiliation":[{"name":"Precision Medicine and Metabolism Laboratory, CIC bioGUNE Basque Research and Technology Alliance  Derio Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Herrera","sequence":"additional","affiliation":[{"name":"Research Unit, Basque Center for Blood Transfusion and Human Tissues Osakidetza  Galdakao Spain"},{"name":"Cell Therapy, Stem Cells and Tissues Group Biocruces Bizkaia Health Research Institute  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Azkarate","sequence":"additional","affiliation":[{"name":"Research Unit, Basque Center for Blood Transfusion and Human Tissues Osakidetza  Galdakao Spain"},{"name":"Cell Therapy, Stem Cells and Tissues Group Biocruces Bizkaia Health Research Institute  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"Vesga","sequence":"additional","affiliation":[{"name":"Research Unit, Basque Center for Blood Transfusion and Human Tissues Osakidetza  Galdakao Spain"},{"name":"Cell Therapy, Stem Cells and Tissues Group Biocruces Bizkaia Health Research Institute  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Eguizabal","sequence":"additional","affiliation":[{"name":"Research Unit, Basque Center for Blood Transfusion and Human Tissues Osakidetza  Galdakao Spain"},{"name":"Cell Therapy, Stem Cells and Tissues Group Biocruces Bizkaia Health Research Institute  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Anguita","sequence":"additional","affiliation":[{"name":"Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE Basque Research and Technology Alliance  Derio Spain"},{"name":"Ikerbasque, Basque Foundation for Science  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nieves","family":"Embade","sequence":"additional","affiliation":[{"name":"Precision Medicine and Metabolism Laboratory, CIC bioGUNE Basque Research and Technology Alliance  Derio Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Mato","sequence":"additional","affiliation":[{"name":"Precision Medicine and Metabolism Laboratory, CIC bioGUNE Basque Research and Technology Alliance  Derio Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Millet","sequence":"additional","affiliation":[{"name":"Precision Medicine and Metabolism Laboratory, CIC bioGUNE Basque Research and Technology Alliance  Derio 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