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Seventy\u2010eight patients participated in this study and underwent magnetic resonance diffusion\u2010weighted imaging. Three regions of interest, including the parotid gland tumor, the peritumor parotid gland, and the contralateral parotid gland, were manually contoured for 92 tumors, including 20 malignant tumors (MTs), 42 Warthin tumors (WTs), and 30 pleomorphic adenomas (PMAs). We recorded multiple apparent diffusion coefficient (ADC) features and applied a machine\u2010learning method with the features to classify the three types of tumors. With only mean ADC of tumors, the area under the curve of the classification model was 0.63, 0.85, and 0.87 for MTs, WTs, and PMAs, respectively. The performance metrics were improved to 0.81, 0.89, and 0.92, respectively, with multiple features. Apart from the ADC features of parotid gland tumor, the features of the peritumor and contralateral parotid glands proved advantageous for tumor classification. Combining machine learning and multiple features provides excellent discrimination of tumor types and can be a practical tool in the clinical diagnosis of parotid gland tumors.<\/jats:p>","DOI":"10.1002\/nbm.4642","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T06:18:25Z","timestamp":1636093105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Improving diagnosing performance for malignant parotid gland tumors using machine learning with multifeatures based on diffusion\u2010weighted magnetic resonance imaging"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5219-0406","authenticated-orcid":false,"given":"Chun\u2010Jung","family":"Juan","sequence":"first","affiliation":[{"name":"Department of Computer Science and Information Engineering National Taiwan University  Taipei Taiwan Republic of China"},{"name":"Department of Medical Imaging 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