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Depending on the prevailing mechanism, transverse relaxation time (<jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>) of water in fixed tissue could increase (when dipole\u2013dipole interaction prevails) or decrease with temperature (when diffusion in the field gradient prevails). Chemical exchange can make <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> even temperature independent. Also, variation of resolution from 100\u2009to 15\u2009\u03bcm\/pxl (or less) affects effective transverse relaxation. <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> steadily decreases with increased resolution (\n, \n is the read direction resolution). TRADE can describe all of these observations (semi)quantitatively. The model has been experimentally verified on water phantoms and on formalin\u2010fixed zebrafish, mouse brain, and rabbit larynx tissues. TRADE could help predict optimal scanning parameters for high\u2010resolution MRM from much faster measurements at lower resolution.<\/jats:p>","DOI":"10.1002\/nbm.4747","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T09:53:41Z","timestamp":1650880421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transverse relaxation in fixed tissue: Influence of temperature and resolution on image contrast in magnetic resonance microscopy"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3652-2962","authenticated-orcid":false,"given":"Ryan","family":"Meloche","sequence":"first","affiliation":[{"name":"Metabolomics Core Mayo Clinic  Rochester Minnesota 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