{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T06:40:39Z","timestamp":1778395239357,"version":"3.51.4"},"reference-count":128,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>The United States is experiencing a dramatic increase in maternal opioid misuse and, consequently, the number of individuals exposed to opioids in utero. Prenatal opioid exposure has both acute and long\u2010lasting effects on health and wellbeing. Effects on the brain, often identified at school age, manifest as cognitive impairment, attention deficit, and reduced scholastic achievement. The neurobiological basis for these effects is poorly understood. Here, we examine how in utero exposure to heroin affects brain development into early adolescence in a mouse model. Pregnant C57BL\/6J mice received escalating doses of heroin twice daily on gestational days 4\u201318. The brains of offspring were assessed on postnatal day 28 using 9.4\u2009T diffusion MRI of postmortem specimens at 36\u2009\u03bcm resolution. Whole\u2010brain volumes and the volumes of 166 bilateral regions were compared between heroin\u2010exposed and control offspring. We identified a reduction in whole\u2010brain volume in heroin\u2010exposed offspring and heroin\u2010associated volume changes in 29 regions after standardizing for whole\u2010brain volume. Regions with bilaterally reduced standardized volumes in heroin\u2010exposed offspring relative to controls include the ectorhinal and insular cortices. Regions with bilaterally increased standardized volumes in heroin\u2010exposed offspring relative to controls include the periaqueductal gray, septal region, striatum, and hypothalamus. Leveraging microscopic resolution diffusion tensor imaging and precise regional parcellation, we generated whole\u2010brain structural MRI diffusion connectomes. Using a dimension reduction approach with multivariate analysis of variance to assess group differences in the connectome, we found that in utero heroin exposure altered structure\u2010based connectivity of the left septal region and the region that acts as a hub for limbic regulatory actions. Consistent with clinical evidence, our findings suggest that prenatal opioid exposure may have effects on brain morphology, connectivity, and, consequently, function that persist into adolescence. This work expands our understanding of the risks associated with opioid misuse during pregnancy and identifies biomarkers that may facilitate diagnosis and treatment.<\/jats:p>","DOI":"10.1002\/nbm.4842","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T08:56:52Z","timestamp":1666169812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3851-8297","authenticated-orcid":false,"given":"Kathryn J.","family":"Hornburg","sequence":"first","affiliation":[{"name":"Department of Radiology, School of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren M.","family":"Slosky","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, School of Medicine Duke University  Durham North Carolina USA"},{"name":"Department of Pharmacology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Cofer","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Porkka","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, School of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas B.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, School of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Pires","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, School of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"Petrella","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard E.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Wetsel","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, School of Medicine Duke University  Durham North Carolina USA"},{"name":"Department of Neurology, School of Medicine Duke University  Durham North Carolina USA"},{"name":"Department of Psychiatry and Behavioral Sciences, School of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Barak","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, School of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc G.","family":"Caron","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, School of Medicine Duke University  Durham North Carolina USA"},{"name":"Department of Neurology, School of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Allan","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine Duke University  Durham North Carolina USA"},{"name":"Department of Biomedical Engineering, Pratt School of Engineering Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15m10386"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0045-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1556740"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1600879"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1954"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2010.08.011"},{"key":"e_1_2_8_8_1","unstructured":"Dramatic increases in maternal opioid use and neonatal abstinence syndrome. National Institute on Drug Abuse and National Institutes of Health. 2019. Accessed December 4 2020.https:\/\/www.drugabuse.gov\/drug-topics\/trends-statistics\/infographics\/dramatic-increases-in-maternal-opioid-use-neonatal-abstinence-syndrome"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.2.235"},{"key":"e_1_2_8_10_1","volume-title":"Neonatal Abstinence Syndrome","author":"Anbalagan S","year":"2020"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2014.02.010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2020.09.009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-14-104"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-0128"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370219883601"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.147"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0393-20.2020"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1262508"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1990.18.4.305"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.06.073"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.7025"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24642"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2134(96)00014-2"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810250035004"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.111"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-01265-w"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.12.033"},{"issue":"12","key":"e_1_2_8_28_1","first-page":"2161","article-title":"White matter injury and structural anomalies in infants with prenatal opioid exposure","volume":"40","author":"Merhar SL","year":"2019","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.03.070"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2014.11.008"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2018.04.004"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2012.05.054"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2017.01.009"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2012.04.008"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1957"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4333-14.2015"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2015.02.002"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-020-02552-3"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2017.09.001"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.161.2.3763909"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(94)80775-1"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.201.3.8939209"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv121"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-018-1750-x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117274"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24560"},{"key":"e_1_2_8_47_1","doi-asserted-by":"crossref","unstructured":"JohnsonGA TianY CoferGP et al.HiDiver: a suite of methods to merge magnetic resonance histology light sheet microscopy and complete brain delineations. February 10 2022.https:\/\/www.biorxiv.org\/content\/10.1101\/2022.02.10.479607","DOI":"10.1101\/2022.02.10.479607"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01285-x"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2018.00083"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20279"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119199"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118576"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(02)00607-7"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.02.058"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2464-4"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14940"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e3283644d15"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.115.128686"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(03)00006-X"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-345-9_11"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.05.013"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-018-9410-0"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2014.00044"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1994.1037"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.067"},{"key":"e_1_2_8_66_1","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2008"},{"key":"e_1_2_8_67_1","doi-asserted-by":"crossref","unstructured":"EvansAC CollinsDL MillsSR et al.3D statistical neuroanatomical models from 305 MRI volumes. In:1993 IEEE Conference Record Nuclear Science Symposium and Medical Imaging Conference. IEEE; 1993:1813\u20101817.","DOI":"10.1109\/NSSMIC.1993.373602"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.007"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.11.028"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2010.2045126"},{"key":"e_1_2_8_72_1","unstructured":"YehFC.DSI Studio: a Tractography Software Tool for Diffusion MRI Analysis. Accessed October 21 2020.https:\/\/dsi-studio.labsolver.org\/"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.06.021"},{"key":"e_1_2_8_74_1","first-page":"273","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1952.10483441"},{"key":"e_1_2_8_76_1","volume-title":"Designing Experiments and Analyzing Data: A Model Comparison Perspective","author":"Maxwell SE","year":"2018"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11930-020-00266-4"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2015.0123"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.2307\/1939922"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.084"},{"key":"e_1_2_8_81_1","unstructured":"LevinK AthreyaA TangM LyzinskiV ParkY PriebeCE.A central limit theorem for an omnibus embedding of multiple random graphs and implications for multiscale network inference. June 26 2019.https:\/\/arxiv.org\/abs\/1705.09355"},{"key":"e_1_2_8_82_1","doi-asserted-by":"crossref","unstructured":"LevinK AthreyaA TangMet al.A central limit theorem for an omnibus embedding of multiple random dot product graphs. In:IEEE International Conference on Data Mining Workshops(ICDMW). IEEE; 2017:964\u2010967.","DOI":"10.1109\/ICDMW.2017.132"},{"issue":"226","key":"e_1_2_8_83_1","first-page":"8393","article-title":"Statistical inference on random dot product graphs: a survey","volume":"18","author":"Athreya A","year":"2018","journal-title":"J Mach Learn Res"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41109-019-0232-2"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2005.09.010"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-27497-8_7"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177730491"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_8_89_1","first-page":"254","volume-title":"Handbook of Biological Statistics","author":"McDonald JH","year":"2014"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-210X.2010.00061.x"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.107"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1961.10482090"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7139.1236"},{"key":"e_1_2_8_94_1","first-page":"175","article-title":"On the use, interpretation of certain test criteria for purposes of statistical inference: part I","volume":"20","author":"Pearson J","year":"1928","journal-title":"Biometrika A"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-3801"},{"key":"e_1_2_8_96_1","unstructured":"Results from the 2016 National Survey on Drug Use and Health: detailed tables. Substance Abuse Center for Behavioral Health Statistics and Quality.2017.https:\/\/www.samhsa.gov\/data\/site\/default\/files\/NSDUH-DetTabs-2016\/NSDUH-DatTabs-2016.htm"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13722-017-0074-0"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(79)90022-7"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20348"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.04.001"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-07-02538.1998"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.041"},{"issue":"5","key":"e_1_2_8_103_1","first-page":"246","article-title":"Prenatal oxycodone exposure alters CNS endothelin receptor expression in neonatal rats","volume":"66","author":"Devarapalli M","year":"2016","journal-title":"Drug Res"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082262"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2013.12.001"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(93)90011-C"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(94)90046-9"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.930734"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(02)00505-2"},{"key":"e_1_2_8_110_1","first-page":"117822181876577","article-title":"Symptoms associated with attention deficit\/hyperactivity disorder and autism spectrum disorders in school\u2010aged children prenatally exposed to substances","volume":"12","author":"Sandtorv LB","year":"2018","journal-title":"Subst Abus"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2008.01870.x"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.02.022"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007899"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-013-1097-7"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.05.010"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.06.026"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206780"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2005282"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1177\/0023677220907617"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811586106"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.152462"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000169"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116922"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht204"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365074"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.03.029"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(01)00012-9"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.04.006"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00197"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.4842","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nbm.4842","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.4842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:03:23Z","timestamp":1760961803000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.4842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,23]]},"references-count":128,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/nbm.4842"],"URL":"https:\/\/doi.org\/10.1002\/nbm.4842","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,23]]},"assertion":[{"value":"2022-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e4842"}}