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One way to differentiate the tissues is to measure the hypoxia status. The purpose of the current study is to correlate the abnormal brain tissue volume derived from magnetic resonance\u2010based imaging of brain oxygen saturation (S<jats:sub>t<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010MRI) to the fluorine\u201018 fluoromisonidazole ([<jats:sup>18<\/jats:sup>F]FMISO) positron emission tomography (PET) volume for hypoxia imaging validation, and to analyze the ability of S<jats:sub>t<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010MRI to depict the different hypoxic tissue types in the acute phase of stroke. In a pertinent model of stroke in the rat, the volume of tissue with decreased S<jats:sub>t<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010MRI signal and that with increased uptake of [<jats:sup>18<\/jats:sup>F]FMISO were equivalent and correlated (r\u2009=\u20090.706; <jats:italic>p<\/jats:italic>\u2009=\u20090.015). The values of S<jats:sub>t<\/jats:sub>O<jats:sub>2<\/jats:sub> in the tissue at risk were significantly greater than those quantified in the core of the lesion, and were less than those for healthy tissue (52.3%\u2009\u00b1\u20092.0%; 43.3%\u2009\u00b1\u20091.9%, and 67.9\u2009\u00b1\u20091.4%, respectively). A threshold value for S<jats:sub>t<\/jats:sub>O<jats:sub>2<\/jats:sub> of \u224860% as the cut\u2010off for the identification of the tissue at risk was calculated. Tissue volumes with reduced S<jats:sub>t<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010MRI correlated with the final lesion (r\u2009=\u20090.964, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The findings show that the S<jats:sub>t<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010MRI approach is sensitive for the detection of hypoxia and for the prediction of the final lesion after stroke. Once validated in acute clinical settings, this approach might be used to enhance the stratification of patients for potential therapeutic interventions.<\/jats:p>","DOI":"10.1002\/nbm.4858","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T05:59:49Z","timestamp":1666763989000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Magnetic resonance imaging of hypoxia in acute stroke compared with fluorine\u201018 fluoromisonidazole\u2010positron\u00a0emission\u00a0tomography:\u00a0A\u00a0cross\u2010validation\u00a0study?"],"prefix":"10.1002","volume":"36","author":[{"given":"Samuel","family":"Valable","sequence":"first","affiliation":[{"name":"Normandie\u2010Univ, UNICAEN, CEA, CNRS, GIP CYCERON, ISTCT\/CERVOxy group  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9031-0907","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Toutain","sequence":"additional","affiliation":[{"name":"Normandie\u2010Univ, UNICAEN, CEA, CNRS, GIP CYCERON, ISTCT\/CERVOxy group  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Divoux","sequence":"additional","affiliation":[{"name":"Normandie\u2010Univ, UNICAEN, CEA, CNRS, GIP CYCERON, ISTCT\/CERVOxy group  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Chazalviel","sequence":"additional","affiliation":[{"name":"Normandie\u2010Univ, UNICAEN, CEA, CNRS, GIP CYCERON, ISTCT\/CERVOxy group  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Corroyer\u2010Dulmont","sequence":"additional","affiliation":[{"name":"Normandie\u2010Univ, UNICAEN, CEA, CNRS, GIP CYCERON, ISTCT\/CERVOxy group  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ararat","family":"Chakhoyan","sequence":"additional","affiliation":[{"name":"Normandie\u2010Univ, UNICAEN, CEA, CNRS, GIP CYCERON, ISTCT\/CERVOxy group  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Guillouet","sequence":"additional","affiliation":[{"name":"Normandie\u2010Univ, UNICAEN, CEA, CNRS, GIP CYCERON, ISTCT\/LDM\u2010TEP group  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Bernaudin","sequence":"additional","affiliation":[{"name":"Normandie\u2010Univ, UNICAEN, CEA, CNRS, GIP CYCERON, ISTCT\/CERVOxy group  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4952-1240","authenticated-orcid":false,"given":"Emmanuel L.","family":"Barbier","sequence":"additional","affiliation":[{"name":"Univ. 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