{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:34:04Z","timestamp":1790876044598,"version":"4.1.0"},"reference-count":76,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671671"],"award-info":[{"award-number":["81671671"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ30814"],"award-info":[{"award-number":["2022JJ30814"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["2021SK53503"],"award-info":[{"award-number":["2021SK53503"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated the fiber bundles in mild traumatic brain injury (mTBI) patients using differential and correlational tractography in a longitudinal analysis. Diffusion MRI data were acquired in 34 mTBI patients at 7\u2009days (acute stage) and 3\u2009months or longer (chronic stage) after mTBI. Trail Making Test A (TMT\u2010A) and Digital Symbol Substitution Test changes were used to evaluate the cognitive performance. Longitudinal correlational tractography showed decreased anisotropy in the corpus callosum during the chronic mTBI stage. The changes in anisotropy in the corpus callosum were significantly correlated with the changes in TMT\u2010A (false discovery rate [FDR]\u2009=\u20090.000094). Individual longitudinal differential tractography found that anisotropy decreased in the corpus callosum in 30 mTBI patients. Group cross\u2010sectional differential tractography found that anisotropy increased (FDR\u2009=\u20090.02) in white matter in the acute mTBI patients, while no changes occurred in the chronic mTBI patients. Our study confirms the feasibility of using correlational and differential tractography as tract\u2010based monitoring biomarkers to evaluate the disease progress of mTBI, and indicates that normalized quantitative anisotropy could be used as a biomarker to monitor the injury and\/or repairs of white matter in individual mTBI patients.<\/jats:p>","DOI":"10.1002\/nbm.4991","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T06:04:54Z","timestamp":1688191494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Differential and correlational tractography as tract\u2010based biomarkers in mild traumatic brain injury: A longitudinal MRI study"],"prefix":"10.1002","volume":"36","author":[{"given":"Si\u2010Hong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang\u2010Cheng","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Bioengineering, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu\u2010Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"MR Scientific Marketing Siemens Healthineers Ltd.  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Xiangya Hospital of Central South University  Changsha China"},{"name":"Department of Radiology Quality Control Center  Changsha China"},{"name":"Clinical Research Center for Medical Imaging in Hunan Province  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30231\u2010X"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23783"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/16501970510027321"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70120\u20106"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww344"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.0815"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00584"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13122343"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118651"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d0ccdd"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000305961.68029.54"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu095"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010017\u20109708\u20109"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080713"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.02.011"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2010.2045126"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.751902"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133001"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010015\u20109386\u20104"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED\u2010D\u201014\u201000413"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.5725"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26143"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010021\u201002364\u2010y"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000146"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116131"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.053"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.103062"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.06.014"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2017.01.012"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2018.07.016"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa193"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2020.0921"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00163"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.248500"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.261939"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760\u2010018\u20100937\u20105"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_11_40_1","volume-title":"Administration and scoring manual: Wechesler adult intelligence scale","author":"WAIS\u2010III WD","year":"1997"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.157834"},{"key":"e_1_2_11_42_1","volume-title":"The Halstead\u2010Reitan neuropsychological test battery: theory and clinical interpretation","author":"Reitan RWD","year":"1993"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617709090626"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803390902881942"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.803066"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010018\u20100663\u2010y"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.05.027"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.06.021"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws073"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3368"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23658"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.1763"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3141"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13269"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23022"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000666"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010020\u201000359\u20107"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828726cc"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2019.1667798"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00616"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.1913"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/nen.0b013e3181461965"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2008.03.004"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.07.014"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000186950.54075.3B"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010011\u20100402\u20106"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005203"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.23843"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25670"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311\u2010021\u201001283\u20102"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010018\u20101985\u20105"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201001285\u2010x"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010017\u20109684\u20100"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617720000879"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010031\u201016431\u20106_17"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(19)30282\u20100"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010087"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.4991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:48:53Z","timestamp":1760957333000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.4991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":76,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/nbm.4991"],"URL":"https:\/\/doi.org\/10.1002\/nbm.4991","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2022-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e4991"}}