{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:27:17Z","timestamp":1785486437857,"version":"3.56.0"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Global agreement in central nervous system (CNS) tumor classification is essential for predicting patient prognosis and determining the correct course of treatment, as well as for stratifying patients for clinical trials at international level. The last update by the World Health Organization of CNS tumor classification and grading in 2021 considered, for the first time,\n                    <jats:italic>IDH<\/jats:italic>\n                    \u2010wildtype glioblastoma and astrocytoma\n                    <jats:italic>IDH<\/jats:italic>\n                    \u2010mutant grade 4 as different tumors. Mutations in the genes isocitrate dehydrogenase (\n                    <jats:italic>IDH<\/jats:italic>\n                    ) 1 and 2 occur early and, importantly, contribute to gliomagenesis.\n                    <jats:italic>IDH<\/jats:italic>\n                    mutation produces a metabolic reprogramming of tumor cells, thus affecting the processes of hypoxia and vascularity, resulting in a clear advantage for those patients who present with\n                    <jats:italic>IDH<\/jats:italic>\n                    \u2010mutated astrocytomas. Despite the clinical relevance of\n                    <jats:italic>IDH<\/jats:italic>\n                    mutation, current protocols do not include full sequencing for every patient. Alternative biomarkers could be useful and complementary to obtain a more reliable classification. In this sense, magnetic resonance imaging (MRI)\u2010perfusion biomarkers, such as relative cerebral blood volume and flow, could be useful from the moment of presurgery, without incurring additional financial costs or requiring extra effort. The main purpose of this work is to analyze the vascular and hemodynamic differences between\n                    <jats:italic>IDH<\/jats:italic>\n                    \u2010wildtype glioblastoma and\n                    <jats:italic>IDH<\/jats:italic>\n                    \u2010mutant astrocytoma. To achieve this, we evaluate and validate the association between dynamic susceptibility contrast\u2010MRI perfusion biomarkers and\n                    <jats:italic>IDH<\/jats:italic>\n                    mutation status. In addition, to gain a deeper understanding of the vascular differences in astrocytomas depending on the\n                    <jats:italic>IDH<\/jats:italic>\n                    mutation, we analyze the transcriptomic bases of the vascular differences.\n                  <\/jats:p>","DOI":"10.1002\/nbm.5004","type":"journal-article","created":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T02:50:39Z","timestamp":1689994239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Vascular differences between\n                    <i>IDH\u2010<\/i>\n                    wildtype glioblastoma and astrocytoma\n                    <i>IDH<\/i>\n                    \u2010mutant grade 4 at imaging and transcriptomic levels"],"prefix":"10.1002","volume":"36","author":[{"given":"Mar\u00eda del Mar","family":"\u00c1lvarez\u2010Torres","sequence":"first","affiliation":[{"name":"Biomedical Data Science Laboratory, ITACA (Instituto de Informaci\u00f3n y Tecnolog\u00eda de las Comunicaciones) Universitat Polit\u00e8cnica de Val\u00e8ncia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"L\u00f3pez\u2010Cerd\u00e1n","sequence":"additional","affiliation":[{"name":"Unidad Mixta de Imagen Biom\u00e9dica FISABIO\u2010CIPF (Centro Investigaci\u00f3n Pr\u00edncipe Felipe)  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoraida","family":"Andreu","sequence":"additional","affiliation":[{"name":"Foundation Valencian Institute of Oncology (FIVO)  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"de la Iglesia Vay\u00e1","sequence":"additional","affiliation":[{"name":"Unidad Mixta de Imagen Biom\u00e9dica FISABIO\u2010CIPF (Centro Investigaci\u00f3n Pr\u00edncipe Felipe)  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elies","family":"Fuster\u2010Garcia","sequence":"additional","affiliation":[{"name":"Biomedical Data Science Laboratory, ITACA (Instituto de Informaci\u00f3n y Tecnolog\u00eda de las Comunicaciones) Universitat Polit\u00e8cnica de Val\u00e8ncia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Garc\u00eda\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Unidad de Bioinform\u00e1tica y Bioestad\u00edstica del CIPF  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Garc\u00eda\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Biomedical Data Science Laboratory, ITACA (Instituto de Informaci\u00f3n y Tecnolog\u00eda de las Comunicaciones) Universitat Polit\u00e8cnica de Val\u00e8ncia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010016\u20101545\u20101"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.07.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201012\u20103002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808710"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12071817"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010019\u20100817\u20100"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.7b00421"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24050968"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010020\u20100814\u2010x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2018.1548935"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010020\u201006702\u20102"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2019.05.002"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26958"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017170845"},{"key":"e_1_2_8_17_1","unstructured":"BoxermanJL SchmaindaKM WeisskoffRM.Relative Cerebral Blood Volume Maps Corrected for Contrast Agent Extravasation Significantly Correlate with Glioma Tumor Grade Whereas Uncorrected Maps Do Not. 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