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This retrospective study included 47 image sets from 22 patients who underwent whole\u2010brain radiotherapy for brain tumors. The data for the normal control group comprised 105 image sets from 105 participants with no pathological changes. DWI was performed with the three MPGs applied in an orthogonal direction to the imaging plane, and apparent diffusion coefficient images for the <jats:italic>x<\/jats:italic>\u2010, <jats:italic>y<\/jats:italic>\u2010, and <jats:italic>z<\/jats:italic>\u2010axes were retrospectively generated. The ALPS index was calculated to quantify interstitial fluid dynamics. The independent <jats:italic>t<\/jats:italic>\u2010test was used to compare the ALPS index between normal controls and patients who underwent whole\u2010brain radiotherapy. Patients were compared in all age groups and individual age groups (20\u201339, 40\u201359, and 60\u201384\u2009years). We also examined the correlation between biologically equivalent doses (BEDs) and the ALPS index, as well as the correlation between white matter hyperintensity and the ALPS index. In the comparison of all age groups, the ALPS index was significantly lower (<jats:italic>p\u2009&lt;<\/jats:italic>\u00a00.001) in the postradiation group (1.32\u2009\u00b1\u20090.16) than in the control group (1.44\u2009\u00b1\u20090.17), suggesting that interstitial fluid dynamics were altered in patients following whole\u2010brain radiotherapy. Significant age group differences were found (40\u201359\u2009years: <jats:italic>p\u2009&lt;<\/jats:italic>\u00a00.01; 60\u201384\u2009years: <jats:italic>p\u2009&lt;<\/jats:italic>\u00a00.001), along with a weak negative correlation between BEDs (<jats:italic>r\u2009=<\/jats:italic>\u2009\u22120.19) and significant correlations between white matter hyperintensity and the ALPS index (<jats:italic>r\u2009=<\/jats:italic>\u2009\u22120.46 for periventricular white matter, <jats:italic>r\u2009=<\/jats:italic>\u2009\u22120.38 for deep white matter). It was concluded that the ALPS method using DWI with orthogonal MPGs suggest alteration in interstitial fluid dynamics in patients after whole\u2010brain radiotherapy. Further systematic prospective studies are required to investigate their association with cognitive symptoms.<\/jats:p>","DOI":"10.1002\/nbm.5030","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T06:33:56Z","timestamp":1694068436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of alterations in interstitial fluid dynamics in cases of whole\u2010brain radiation using the diffusion\u2010weighted image analysis along the perivascular space method"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-0240","authenticated-orcid":false,"given":"Toshiaki","family":"Taoka","sequence":"first","affiliation":[{"name":"Department of Innovative Biomedical Visualization (iBMV) Nagoya University  Nagoya Japan"},{"name":"Department of Radiology Nagoya University  Nagoya 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