{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:35:17Z","timestamp":1761006917519,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Magnetic resonance elastography (MRE) is an accurate noninvasive diagnostic tool for assessing the stiffness of parenchymal organs, including the spleen. However, this measurement may be biased due to postprandial changes in splenic stiffness. The aim of the current study was to evaluate postprandial changes in spleen stiffness assessed by MRE in a large sample of healthy volunteers. This was a prospective institutional research ethics board\u2010approved study. Healthy volunteers with no history of liver disease were recruited for an MRE test and blood draw from December 2018 to July 2019. Each participant underwent spleen MRE after at least 4\u2009h of fasting and again 30\u2009min after a 1000\u2009kcal meal. Also, 14 randomly selected volunteers underwent additional MRE examinations at 1.5 and 2.5\u2009h after food intake. The MRE data were acquired at 60\u2009Hz using a 1.5\u2010T MRI scanner. The spleen stiffness was assessed using a weighted mean of stiffness values from regions of interest manually drawn on three to five spleen slices. Spearman's rank correlation, Wilcoxon signed\u2010rank, Friedman, and Mann\u2013Whitney tests were used for statistical analysis. A total of 100 volunteers met the inclusion criteria and were eventually enrolled in this study (age 23\u2009\u00b1\u20092\u2009years; 65 women). The mean spleen stiffness for the whole group increased by 7.9% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) from the mean \u00b1 SD value of 5.09\u2009\u00b1\u20090.63 (95% CI: 4.96\u20135.21) kPa in the fasting state to 5.47\u2009\u00b1\u20090.66 (95% CI 5.34\u20135.60) kPa 30\u2009min after the meal and then gradually decreased. However, even 2\u2009h 30\u2009min after the meal, the spleen stiffness was higher than in the fasting state. This difference was statistically significant at <jats:italic>p<\/jats:italic>\u00a0less than\u20090.001. It was concluded that meal intake results in a statistically significant elevation of spleen stiffness that persists for 2.5\u2009h. This finding supports the recommendation for routine fasting for more than 2.5 h prior to assessing MRE\u2010based spleen stiffness.<\/jats:p>","DOI":"10.1002\/nbm.5047","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:51:06Z","timestamp":1696877466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Postprandial splenic stiffness changes on magnetic resonance elastography in a young healthy population"],"prefix":"10.1002","volume":"37","author":[{"given":"Marzanna","family":"Obrzut","sequence":"first","affiliation":[{"name":"Institute of Health Sciences, Medical College University of Rzeszow  Rzeszow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitaliy","family":"Atamaniuk","sequence":"additional","affiliation":[{"name":"Department of Biophysics, College of Natural Sciences, Institute of Physics University of Rzeszow  Rzeszow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Ehman","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Cholewa","sequence":"additional","affiliation":[{"name":"Department of Biophysics, College of Natural Sciences, Institute of Physics University of Rzeszow  Rzeszow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Gutkowski","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, Medical College University of Rzeszow  Rzeszow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Domka","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Institute of Medical Sciences, Medical College University of Rzeszow  Rzeszow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Obrzut","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Medical Sciences, Medical College University of Rzeszow  Rzeszow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261\u2010017\u20101314\u20101"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2020.03.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.10.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5603\/GP.a2020.0067"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/rmr.0000000000000182"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.722703"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.10.5989"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261\u2010020\u201002628\u2010x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010022\u201008935\u20109"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24505"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i3.308"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2017.1374852"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010014\u20103124\u2010y"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14130916"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24049"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14981"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173992"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201099243\u20107"},{"key":"e_1_2_8_20_1","unstructured":"BotzB.Radiology calculators. 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