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While associations between baseline metabolite levels and behaviours can be insightful, assessing the neurometabolic response of GABA and glutamate during social processing may explain altered neurochemical function in more depth. Thus far, there have been no attempts to determine whether changes in metabolite levels are detectable using functional MRS (fMRS) during social processing in a control population. We performed Mescher\u2013Garwood point resolved spectroscopy edited fMRS to measure the dynamic response of GABA and glutamate in the superior temporal sulcus (STS) and visual cortex (V1) while viewing social stimuli, using a design that allows for analysis in both block and event\u2010related approaches. Sliding window analyses were used to investigate GABA and glutamate dynamics at higher temporal resolution. The changes of GABA and glutamate levels with social stimulus were largely non\u2010significant. A small decrease in GABA levels was observed during social stimulus presentation in V1, but no change was observed in STS. Conversely, non\u2010social stimulus elicited changes in both GABA and glutamate levels in both regions. Our findings suggest that the current experimental design primarily captures effects of visual stimulation, not social processing. Here, we discuss the feasibility of using fMRS analysis approaches to assess changes in metabolite response.<\/jats:p>","DOI":"10.1002\/nbm.5092","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T18:30:20Z","timestamp":1703788220000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["GABA and glutamate response to social processing: a functional MRS feasibility study"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6921-2915","authenticated-orcid":false,"given":"Duanghathai","family":"Pasanta","sequence":"first","affiliation":[{"name":"Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry, Psychology, and Neuroscience, King's College London  London UK"},{"name":"Department of Radiologic Technology, Faculty of Associated Medical Sciences Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"White","sequence":"additional","affiliation":[{"name":"Centre for Human Psychopharmacology &amp; 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