{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:45:17Z","timestamp":1791488717807,"version":"4.3.4"},"reference-count":77,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008978","name":"Philips Oral Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008978","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Liver T<jats:sub>1<\/jats:sub> mapping techniques typically require long breath holds or long scan time in free\u2010breathing, need correction for \n inhomogeneities and process composite (water and fat) signals. The purpose of this work is to accelerate the multi\u2010slice acquisition of liver water selective T<jats:sub>1<\/jats:sub> (wT<jats:sub>1<\/jats:sub>) mapping in a single breath hold, improving the <jats:italic>k<\/jats:italic>\u2010space sampling efficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The proposed continuous inversion\u2010recovery (IR) Look\u2010Locker methodology combines a single\u2010shot gradient echo spiral readout, Dixon processing and a dictionary\u2010based analysis for liver wT<jats:sub>1<\/jats:sub> mapping at 3\u2009T. The sequence parameters were adapted to obtain short scan times. The influence of fat, \n inhomogeneities and TE on the estimation of T<jats:sub>1<\/jats:sub> was first assessed using simulations. The proposed method was then validated in a phantom and in 10 volunteers, comparing it with MRS and the modified Look\u2010Locker inversion\u2010recovery (MOLLI) method. Finally, the clinical feasibility was investigated by comparing wT<jats:sub>1<\/jats:sub> maps with clinical scans in nine patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The phantom results are in good agreement with MRS. The proposed method encodes the IR\u2010curve for the liver wT<jats:sub>1<\/jats:sub> estimation, is minimally sensitive to \n inhomogeneities and acquires one slice in 1.2\u2009s. The volunteer results confirmed the multi\u2010slice capability of the proposed method, acquiring nine\u00a0slices in a breath hold of 11\u2009s. The present work shows robustness to \n inhomogeneities (\n, good repeatability (\n and is in better agreement with MRS (\n than is MOLLI (\n. The wT<jats:sub>1<\/jats:sub> maps in patients captured diverse lesions, thus showing their clinical feasibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A single\u2010shot spiral acquisition can be combined with a continuous IR Look\u2010Locker method to perform rapid repeatable multi\u2010slice liver water T<jats:sub>1<\/jats:sub> mapping at a rate of 1.2\u2009s per slice without a \n map. The proposed method is suitable for nine\u2010slice liver clinical applications acquired in a single breath hold of 11\u2009s.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nbm.5097","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T04:55:33Z","timestamp":1706158533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Accelerated liver water T<sub>1<\/sub> mapping using single\u2010shot continuous inversion\u2010recovery spiral imaging"],"prefix":"10.1002","volume":"37","author":[{"given":"Elizabeth","family":"Huaroc Moquillaza","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, School of Medicine, Klinikum rechts der Isar Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kilian","family":"Weiss","sequence":"additional","affiliation":[{"name":"Philips GmbH  Hamburg 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