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These gas challenges induce T2*\u2010weighted MRI signal losses, after which tracer kinetics modeling was applied to calculate cerebral perfusion. This work compares three gas challenges, desaturation (transient hypoxia), resaturation (transient normoxia), and SineO<jats:sub>2<\/jats:sub> (sinusoidal modulation of end\u2010tidal oxygen pressures) in a cohort of 10 healthy volunteers (age 37\u2009\u00b1\u200911 years; 60% female). Perfusion estimates consisted of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT). Calculations were computed using a traditional tracer kinetics model in the time domain for desaturation and resaturation and in the frequency domain for SineO<jats:sub>2<\/jats:sub>. High correlations and limits of agreement were observed among the three deoxygenation\u2010based paradigms for CBV, although MTT and CBF estimates varied with the hypoxic stimulus. Cross\u2010modality correlation with gadolinium DSC was lower, particularly for MTT, but on a par with agreement between the other perfusion references. Overall, this work demonstrated the feasibility and reliability of oxygen respiratory challenges to measure brain perfusion. 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