{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:18Z","timestamp":1786978398959,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T00:00:00Z","timestamp":1708214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008955","name":"Wilhelmina Kinderziekenhuis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Amide proton transfer weighted (APTw) imaging enables in vivo assessment of tissue\u2010bound mobile proteins and peptides through the detection of chemical exchange saturation transfer. Promising applications of APTw imaging have been shown in adult brain tumors. As pediatric brain tumors differ from their adult counterparts, we investigate the radiological appearance of pediatric brain tumors on APTw imaging. APTw imaging was conducted at 3\u2009T. APTw maps were calculated using magnetization transfer ratio asymmetry at 3.5\u2009ppm. First, the repeatability of APTw imaging was assessed in a phantom and in five healthy volunteers by calculating the within\u2010subject coefficient of variation (wCV). APTw images of pediatric brain tumor patients were analyzed retrospectively. APTw levels were compared between solid tumor tissue and normal\u2010appearing white matter (NAWM) and between pediatric high\u2010grade glioma (pHGG) and pediatric low\u2010grade glioma (pLGG) using\n                    <jats:italic>t<\/jats:italic>\n                    \u2010tests. APTw maps were repeatable in supratentorial and infratentorial brain regions (wCV ranged from 11% to 39%), except those from the pontine region (wCV between 39% and 50%). APTw images of 23 children with brain tumor were analyzed (mean age 12\u2009years\u2009\u00b1\u20095, 12 male). Significantly higher APTw values are present in tumor compared with NAWM for both pHGG and pLGG (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u20090.05). APTw values were higher in pLGG subtype pilocytic astrocytoma compared with other pLGG subtypes (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u20090.05). Non\u2010invasive characterization of pediatric brain tumor biology with APTw imaging could aid the radiologist in clinical decision\u2010making.\n                  <\/jats:p>","DOI":"10.1002\/nbm.5122","type":"journal-article","created":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T23:06:32Z","timestamp":1708297592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Amide proton transfer weighted imaging in pediatric neuro\u2010oncology: initial experience"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3797-711X","authenticated-orcid":false,"given":"Iris V.","family":"Obdeijn","sequence":"first","affiliation":[{"name":"Center for Image Sciences, High Field MR Research Group University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evita C.","family":"Wiegers","sequence":"additional","affiliation":[{"name":"Center for Image Sciences, High Field MR Research Group University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lejla","family":"Alic","sequence":"additional","affiliation":[{"name":"Magnetic Detection and Imaging Group, Technical Medical Center University of Twente  Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine L. A.","family":"Plasschaert","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neuro\u2010Oncology Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00ebtte E. G.","family":"Kranendonk","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Laboratory Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans M.","family":"Hoogduin","sequence":"additional","affiliation":[{"name":"Center for Image Sciences, High Field MR Research Group University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W. J.","family":"Klomp","sequence":"additional","affiliation":[{"name":"Center for Image Sciences, High Field MR Research Group University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannie P.","family":"Wijnen","sequence":"additional","affiliation":[{"name":"Center for Image Sciences, High Field MR Research Group University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten H.","family":"Lequin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neuro\u2010Oncology Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine University of Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.74510"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20101541\u20105_3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2018.04.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000717"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555\u2010019\u201009824\u20102"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/cns\u20102018\u20100007"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.72.7511"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3174\/AJNR.A6358"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40658\u2010016\u20100155\u20102"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22761"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/JMRI.26645"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5301"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24067"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25159"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201018\u20101233"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015142979"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2009.09.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010018\u20104194\u20109"},{"key":"e_1_2_9_20_1","unstructured":"van deVenK KeuppJ.Amide Proton Transfer Weighted Imaging: Advancement in Molecular Tumor Diagnosis. White paper. Philips;2018."},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.26322"},{"key":"e_1_2_9_22_1","unstructured":"KeuppJ TogaoO.Magnetization transfer ratio based metric for APTw or CESTw MRI suppressing signal from fluid compartments\u2014initial application to glioblastoma assessment.Proc Int Soc Magn Reson Med.2018;26:3156."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2009.2035616"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2006.01.015"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not158"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010021\u201008039\u2010w\/Published"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MRIC.2021.06.012"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010018\u201002152\u20102"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073809342005"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010802997\u20108.00005\u20100"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.13019"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CCELL.2020.03.011"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/FONC.2020.574974"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWU374"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.29241"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00330\u2010015\u20104188\u2010Z\/METRICS"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/NBM.4717"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1799"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.5122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:55:14Z","timestamp":1760957714000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.5122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,18]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/nbm.5122"],"URL":"https:\/\/doi.org\/10.1002\/nbm.5122","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,18]]},"assertion":[{"value":"2023-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5122"}}